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    FHN1 Fhn1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FHN1
    Official Full Name
    Fhn1p
    Primary source
    SGD:S000003363
    Locus tag
    YGR131W
    See related
    AllianceGenome:SGD:S000003363; FungiDB:YGR131W; VEuPathDB:YGR131W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein localization to plasma membrane. Located in cell periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FHN1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (754726..755250)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Syf2p Neighboring gene uncharacterized protein Neighboring gene prohibitin subunit PHB1 Neighboring gene E2 ubiquitin-protein ligase peroxin 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plasma Membrane Protein Nce102 Modulates Morphology and Function of the Yeast Vacuole. Vaskovicova K, et al. Biomolecules, 2020 Oct 23. PMID 33114062, Free PMC Article
    2. Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. Agarwal AK, et al. J Biol Chem, 2003 Sep 12. PMID 12824174
    3. C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane. Loibl M, et al. Eukaryot Cell, 2010 Aug. PMID 20581291, Free PMC Article
    4. Plasma membrane microdomains regulate turnover of transport proteins in yeast. Grossmann G, et al. J Cell Biol, 2008 Dec 15. PMID 19064668, Free PMC Article
    5. The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways. Woods K, et al. Mol Microbiol, 2016 Feb. PMID 26448198

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in eisosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in eisosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fhn1p
    NP_011647.1
    • hypothetical protein; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      754726..755250
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181260.1 → NP_011647.1  TPA: Fhn1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUR3, P53279
      UniProtKB/TrEMBL
      A6ZUE5, B3LI97, C7GUG4, C8Z924, G2WEL3, N1P9W8
      Conserved Domains (1) summary
      pfam01284
      Location:6 → 138
      MARVEL; Membrane-associating domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53279.1

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