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    LEU1 3-isopropylmalate dehydratase LEU1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852875, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LEU1
    Official Full Name
    3-isopropylmalate dehydratase LEU1
    Primary source
    SGD:S000002977
    Locus tag
    YGL009C
    See related
    AllianceGenome:SGD:S000002977; FungiDB:YGL009C; VEuPathDB:YGL009C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-isopropylmalate dehydratase activity. Involved in L-leucine biosynthetic process. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LEU1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (476313..478652, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit alpha 1 Neighboring gene Mpo1p Neighboring gene H(+)-exporting P2-type ATPase PMA1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. Bigelis R, et al. J Biol Chem, 1976 Jun 25. PMID 6456
    2. Complete sequence of the Saccharomyces cerevisiae LEU1 gene encoding isopropylmalate isomerase. Skala J, et al. Yeast, 1991 Apr. PMID 1840714
    3. Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2. Hsu YP, et al. J Biol Chem, 1984 Mar 25. PMID 6323436
    4. Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmic isopropylmalate isomerase Leu1 in Saccharomyces cerevisiae. Pandey AK, et al. Mitochondrion, 2023 Mar. PMID 36773733
    5. Biosynthesis of branched-chain amino acids in yeast: correlation of biochemical blocks and genetic lesions in leucine auxotrophs. Satyanarayana T, et al. J Bacteriol, 1968 Dec. PMID 5724969, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmic isopropylmalate isomerase Leu1 in Saccharomyces cerevisiae.
      Title: Essential mitochondrial role in iron-sulfur cluster assembly of the cytoplasmic isopropylmalate isomerase Leu1 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-isopropylmalate dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteinogenic amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 3-isopropylmalate dehydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3-isopropylmalate dehydratase LEU1
    NP_011506.1
    • Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      476313..478652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180874.1 → NP_011506.1  TPA: 3-isopropylmalate dehydratase LEU1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC8, P07264
      UniProtKB/TrEMBL
      G2WE84, N1P9T2
      Conserved Domains (2) summary
      TIGR00171
      Location:545 → 736
      leuD; 3-isopropylmalate dehydratase, small subunit
      PRK05478
      Location:9 → 480
      PRK05478; 3-isopropylmalate dehydratase large subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07264.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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