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    VAB2 Vab2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856713, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VAB2
    Official Full Name
    Vab2p
    Primary source
    SGD:S000000731
    Locus tag
    YEL005C
    See related
    AllianceGenome:SGD:S000000731; FungiDB:YEL005C; VEuPathDB:YEL005C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VAB31
    Summary
    Involved in endosome organization and regulation of protein localization. Located in cytoplasm. Part of BLOC-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VAB2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (145907..146755, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Mit1p Neighboring gene NAD+ transporter Neighboring gene Yea4p Neighboring gene tubulin-binding prefolding complex subunit GIM4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. Pan X, et al. Mol Biol Cell, 2000 Jul. PMID 10888680, Free PMC Article
    2. Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1. Hayes MJ, et al. Traffic, 2011 Mar. PMID 21159114, Free PMC Article
    3. Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes. Tang F, et al. Traffic, 2006 Oct. PMID 16824055
    4. The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3. John Peter AT, et al. J Cell Biol, 2013 Apr 1. PMID 23547030, Free PMC Article
    5. Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole. Rana M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25971802, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of BLOC-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vab2p
    NP_010911.3
    • Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      145907..146755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178820.3 → NP_010911.3  TPA: Vab2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010911.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZQU2, D3DLP2, P40003
      UniProtKB/TrEMBL
      C7GKH4, C8Z6Z4, G2WCM6, N1P7F7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40003.1

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