U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    YPS7 putative aspartic endopeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851950, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    YPS7
    Official Full Name
    putative aspartic endopeptidase
    Primary source
    SGD:S000002757
    Locus tag
    YDR349C
    See related
    AllianceGenome:SGD:S000002757; FungiDB:YDR349C; VEuPathDB:YDR349C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See YPS7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1172386..1174176, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRP1 Neighboring gene Pal1p Neighboring gene tRNA-Met Neighboring gene Atp22p

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene. Olsen V, et al. Biochem J, 1999 Apr 15. PMID 10191273, Free PMC Article
    2. HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha. Sohn MJ, et al. Yeast, 2012 Jan. PMID 22162039
    3. Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae. Cho EY, et al. J Biotechnol, 2010 Aug 20. PMID 20599573
    4. Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Krysan DJ, et al. Eukaryot Cell, 2005 Aug. PMID 16087741, Free PMC Article
    5. Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan. Grbavac A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Mar. PMID 27965112

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    putative aspartic endopeptidase
    NP_010636.1
    • Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1172386..1174176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180657.1 → NP_010636.1  TPA: putative aspartic endopeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010636.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSX9, Q06325, Q66RD4
      UniProtKB/TrEMBL
      A6ZYU9, B3LFV1, B5VGN0, N1P783
      Conserved Domains (1) summary
      cl11403
      Location:162 → 442
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06325.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools