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    DET1 acid phosphatase DET1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DET1
    Official Full Name
    acid phosphatase DET1
    Primary source
    SGD:S000002458
    Locus tag
    YDR051C
    See related
    AllianceGenome:SGD:S000002458; FungiDB:YDR051C; VEuPathDB:YDR051C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acid phosphatase activity. Involved in intracellular sterol transport. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DET1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (557056..558060, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vms1p Neighboring gene triose-phosphate isomerase TPI1 Neighboring gene protein serine/threonine kinase activating protein DBF4 Neighboring gene SCF E2 ubiquitin-protein ligase catalytic subunit CDC34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome. Ho CK, et al. PLoS One, 2009 Sep 15. PMID 19753119, Free PMC Article
    2. Phenotypic heterogeneity can enhance rare-cell survival in 'stress-sensitive' yeast populations. Bishop AL, et al. Mol Microbiol, 2007 Jan. PMID 17176259
    3. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
    4. A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis. Louie RJ, et al. Genome Med, 2012 Dec 27. PMID 23270647, Free PMC Article
    5. Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors. Woodford MR, et al. Cell Rep, 2016 Feb 2. PMID 26804907, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DET1 is involved in intracellular sterol transport.
      Title: Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acid phosphatase DET1
    NP_010336.3
    • Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      557056..558060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180359.3 → NP_010336.3  TPA: acid phosphatase DET1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010336.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS38, P87337, Q05314, Q7LHX4, Q99288
      UniProtKB/TrEMBL
      A6ZY17, B3LGL7, C7GT99, C8Z4X0, G2WAF6, N1P826
      Conserved Domains (1) summary
      pfam00300
      Location:27 → 321
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99288.1

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