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    EHD3 mitochondrial 37S ribosomal protein EHD3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    EHD3
    Official Full Name
    mitochondrial 37S ribosomal protein EHD3
    Primary source
    SGD:S000002443
    Locus tag
    YDR036C
    See related
    AllianceGenome:SGD:S000002443; FungiDB:YDR036C; VEuPathDB:YDR036C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    mS47
    Summary
    Enables 3-hydroxyisobutyryl-CoA hydrolase activity. A structural constituent of ribosome. Predicted to be involved in valine catabolic process. Located in mitochondrion. Part of mitochondrial small ribosomal subunit. Human ortholog(s) of this gene implicated in 3-hydroxyisobutryl-CoA hydrolase deficiency. Orthologous to human HIBCH (3-hydroxyisobutyryl-CoA hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See EHD3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (523211..524713, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP3 Neighboring gene 3-deoxy-7-phosphoheptulonate synthase ARO3 Neighboring gene lysine--tRNA ligase KRS1 Neighboring gene putative Na(+)-exporting P-type ATPase ENA5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biochemistry of peroxisomal beta-oxidation in the yeast Saccharomyces cerevisiae. Hiltunen JK, et al. FEMS Microbiol Rev, 2003 Apr. PMID 12697341
    2. Functional analysis of six ORFs from Saccharomyces cerevisiae chromosome IV: two-spored asci produced by disruptant of YDR027c and strain-dependent DNA heterogeneity around YDR036c. Aittamaa M, et al. Yeast, 2001 Jul. PMID 11447599
    3. Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Wiederkehr A, et al. Yeast, 2001 Jun. PMID 11378903
    4. Assessing systems properties of yeast mitochondria through an interaction map of the organelle. Perocchi F, et al. PLoS Genet, 2006 Oct 20. PMID 17054397, Free PMC Article
    5. Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Reinders J, et al. Mol Cell Proteomics, 2007 Nov. PMID 17761666

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-hydroxyisobutyryl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial 37S ribosomal protein EHD3
    NP_010321.1
    • 3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      523211..524713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180344.1 → NP_010321.1  TPA: mitochondrial 37S ribosomal protein EHD3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS24, P28817, Q66RH2
      UniProtKB/TrEMBL
      A6ZY04, B3LGM9, C7GQ14, C8Z4V8
      Conserved Domains (1) summary
      pfam16113
      Location:48 → 386
      ECH_2; Enoyl-CoA hydratase/isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28817.2

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