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    USO1 Uso1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851501, updated on 9-Dec-2024

    Summary

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    Official Symbol
    USO1
    Official Full Name
    Uso1p
    Primary source
    SGD:S000002216
    Locus tag
    YDL058W
    See related
    AllianceGenome:SGD:S000002216; FungiDB:YDL058W; VEuPathDB:YDL058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    INT1
    Summary
    Involved in Golgi vesicle docking; SNARE complex assembly; and endoplasmic reticulum to Golgi vesicle-mediated transport. Located in ER to Golgi transport vesicle membrane and Golgi membrane. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See USO1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (345665..351037)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tsr1p Neighboring gene Rad59p Neighboring gene uncharacterized protein Neighboring gene transcription factor MBP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A cytoskeleton-related gene, uso1, is required for intracellular protein transport in Saccharomyces cerevisiae. Nakajima H, et al. J Cell Biol, 1991 Apr. PMID 2010462, Free PMC Article
    2. Antigenic and functional conservation of an integrin I-domain in Saccharomyces cerevisiae. Hostetter MK, et al. Biochem Mol Med, 1995 Aug. PMID 7582869
    3. Uso1 protein contains a coiled-coil rod region essential for protein transport from the ER to the Golgi apparatus in Saccharomyces cerevisiae. Seog DH, et al. J Biochem, 1994 Dec. PMID 7706227
    4. Specific membrane recruitment of Uso1 protein, the essential endoplasmic reticulum-to-Golgi tethering factor in yeast vesicular transport. Noda Y, et al. J Cell Biochem, 2007 Jun 1. PMID 17192843
    5. Molecular characterization of the USO1 gene product which is essential for vesicular transport in Saccharomyces cerevisiae. Seog DH, et al. Biochem Biophys Res Commun, 1994 Apr 15. PMID 8166741

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi vesicle docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Golgi vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in SNARE complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ER to Golgi transport vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Uso1p
    NP_010225.1
    • Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      345665..351037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180117.1 → NP_010225.1  TPA: Uso1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010225.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRT8, E9PAG8, P25386, P89892, Q07380
      UniProtKB/TrEMBL
      B3LGV6
      Conserved Domains (3) summary
      COG1196
      Location:898 → 1733
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04869
      Location:366 → 715
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      NF033777
      Location:783 → 915
      M_group_A_cterm; M protein C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25386.2

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