SEN54 tRNA splicing endonuclease subunit SEN54 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SEN54
Official Full Name: tRNA splicing endonuclease subunit SEN54
Primary source: SGD:S000006004
Locus tag: YPL083C
See related: AllianceGenome:SGD:S000006004; FungiDB:YPL083C; VEuPathDB:YPL083C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to tRNA-intron endonuclease activity. Involved in tRNA-type intron splice site recognition and cleavage. Located in mitochondrial outer membrane. Part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to tRNA-intron endonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA-type intron splice site recognition and cleavage	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA-type intron splice site recognition and cleavage	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA-intron endonuclease complex	IBA Inferred from Biological aspect of Ancestor more info
part_of tRNA-intron endonuclease complex	IDA Inferred from Direct Assay more info	PubMed

NP_015242.1

Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface

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The following sections contain reference sequences that belong to a specific genome build. Explain