KTR5 putative mannosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KTR5
Official Full Name: putative mannosyltransferase
Primary source: SGD:S000004974
Locus tag: YNL029C
See related: AllianceGenome:SGD:S000004974; FungiDB:YNL029C; VEuPathDB:YNL029C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in cell wall mannoprotein biosynthetic process; mannosylation; and protein N-linked glycosylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KTR5 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (577205..578773, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KTR4, KTR5 and KTR7 have a redundant activity in the S. cerevisiae N-linked glycosylation pathway, but KTR4 plays a major role in O-linked glycan synthesis.
Title: Saccharomyces cerevisiae KTR4, KTR5 and KTR7 encode mannosyltransferases differentially involved in the N- and O-linked glycosylation pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-1,2-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell wall mannoprotein biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosylation	IC Inferred by Curator more info	PubMed
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative mannosyltransferase

NP_014369.3

Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

577205..578773 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182868.3 → NP_014369.3 TPA: putative mannosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014369.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1F0, P53966

UniProtKB/TrEMBL

C7GWP6

Conserved Domains (1) summary

COG5020
Location:6 → 499

KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]