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    JJJ1 Jjj1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855495, updated on 9-Dec-2024

    Summary

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    Official Symbol
    JJJ1
    Official Full Name
    Jjj1p
    Primary source
    SGD:S000005171
    Locus tag
    YNL227C
    See related
    AllianceGenome:SGD:S000005171; FungiDB:YNL227C; VEuPathDB:YNL227C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity. Involved in endocytosis and ribosome biogenesis. Located in cytosol and nucleolus. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See JJJ1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (220659..222431, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene elongin A Neighboring gene glutathione peroxidase Neighboring gene Cnm67p Neighboring gene Sqs1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved domain important for association of eukaryotic J-protein co-chaperones Jjj1 and Zuo1 with the ribosome. Kaschner LA, et al. Biochim Biophys Acta, 2015 May. PMID 25639645, Free PMC Article
    2. Deletion of JJJ1 improves acetic acid tolerance and bioethanol fermentation performance of Saccharomyces cerevisiae strains. Wu X, et al. Biotechnol Lett, 2016 Jul. PMID 27067354
    3. The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1. Meyer AE, et al. J Biol Chem, 2010 Jan 8. PMID 19901025, Free PMC Article
    4. Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits. Lee K, et al. Nat Struct Mol Biol, 2016 Nov. PMID 27669034, Free PMC Article
    5. Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Ghosh A, et al. Cell Mol Life Sci, 2019 Apr. PMID 30683983, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. biochemically characterized ribosomal complexes of the yeast 60S-biogenesis factor Arx1 and late-maturation factors Rei1 and Jjj1 and determined their cryo-EM structures
      Title: Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
    2. Jjj1 and Zuo1, function together with their partner Hsp70 proteins to mediate the biogenesis of ribosomes themselves. Jjj1 and Zuo1 have overlapping but distinct functions in this complex process
      Title: A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis.
    3. both Rei1 and Jjj1 are required for dissociation of Arx1 from the pre-60 S subunit, and the region of Jjj1 that mediates interaction with Rei1 is required in vivo for 60 S subunit biogenesis
      Title: The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.
    4. Preferentially required for the release of pre-ribosomal shuttling factors Arx1 and Alb1 from the cytoplasmic pre-60S particles.
      Title: The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae.
    5. Jjj1, when overexpressed, is able to partially substitute for the Zuo1:Ssb chaperone machinery by recruiting Ssa to the ribosome, facilitating its interaction with nascent polypeptide chains
      Title: The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size HMP PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Jjj1p
    NP_014172.1
    • Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      220659..222431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183065.1 → NP_014172.1  TPA: Jjj1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014172.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0W4, P53863
      UniProtKB/TrEMBL
      B3LP69, C7GPD1, C8ZG07
      Conserved Domains (4) summary
      COG5269
      Location:6 → 275
      ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
      PRK10767
      Location:1 → 67
      PRK10767; chaperone protein DnaJ; Provisional
      sd00020
      Location:340 → 362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12171
      Location:338 → 363
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53863.1

    Gene LinkOut

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