U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CLU1 translation initiation factor 3 subunit CLU1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855025, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CLU1
    Official Full Name
    translation initiation factor 3 subunit CLU1
    Primary source
    SGD:S000004614
    Locus tag
    YMR012W
    See related
    AllianceGenome:SGD:S000004614; FungiDB:YMR012W; VEuPathDB:YMR012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    TIF31
    Summary
    Enables RNA binding activity. Predicted to be involved in intracellular distribution of mitochondria. Located in cytoplasmic stress granule. Orthologous to human CLUH (clustered mitochondria homolog). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CLU1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (291134..294967)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT2 Neighboring gene tRNA-Glu Neighboring gene dolichol kinase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The S. cerevisiae CLU1 and D. discoideum cluA genes are functional homologues that influence mitochondrial morphology and distribution. Fields SD, et al. J Cell Sci, 1998 Jun. PMID 9601101
    2. Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein. Naranda T, et al. J Biol Chem, 1994 Dec 23. PMID 7798228
    3. Characterization of the p33 subunit of eukaryotic translation initiation factor-3 from Saccharomyces cerevisiae. Hanachi P, et al. J Biol Chem, 1999 Mar 26. PMID 10085088
    4. A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes. Vornlocher HP, et al. J Biol Chem, 1999 Jun 11. PMID 10358023
    5. Translation initiation factor eIF3 promotes programmed stop codon readthrough. Beznosková P, et al. Nucleic Acids Res, 2015 May 26. PMID 25925566, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular distribution of mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    translation initiation factor 3 subunit CLU1
    NP_013725.1
    • Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      291134..294967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182508.1 → NP_013725.1  TPA: translation initiation factor 3 subunit CLU1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013725.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI6, Q03690
      UniProtKB/TrEMBL
      A6ZM73, N1NYL3
      Conserved Domains (4) summary
      cd15466
      Location:690 → 931
      CLU-central; An uncharacterized central domain of CLU mitochondrial proteins
      pfam13424
      Location:1019 → 1071
      TPR_12; Tetratricopeptide repeat
      pfam13236
      Location:360 → 595
      CLU; Clustered mitochondria
      pfam15044
      Location:49 → 124
      CLU_N; Mitochondrial function, CLU-N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03690.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools