Ier3ip1 immediate early response 3 interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ier3ip1provided by MGI
Official Full Name: immediate early response 3 interacting protein 1provided by MGI
Primary source: MGI:MGI:1913441
See related: Ensembl:ENSMUSG00000090000 AllianceGenome:MGI:1913441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110057H19Rik
Summary: Predicted to be involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of secretion by cell; and regulation of fibroblast apoptotic process. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Predicted to be active in COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum membrane. Is expressed in several structures, including clavicle; lung; nervous system; nose; and submandibular gland primordium. Orthologous to human IER3IP1 (immediate early response 3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 27.5), CNS E18 (RPKM 24.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 51.98 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (77017723..77029310)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (76930027..76941614)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of beta cells.
Title: IER3IP1 is critical for maintaining glucose homeostasis through regulating the endoplasmic reticulum function and survival of β cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

AV026606 (e-PCR)
- UniSTS:186135

RH125362 (e-PCR)
- UniSTS:162184

AI644142 (e-PCR)
- UniSTS:181149

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in organ growth	ISO Inferred from Sequence Orthology more info
involved_in organ growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extracellular matrix constituent secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: immediate early response 3-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.