Trdn triadin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trdnprovided by MGI
Official Full Name: triadinprovided by MGI
Primary source: MGI:MGI:1924007
See related: Ensembl:ENSMUSG00000019787 AllianceGenome:MGI:1924007
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TDN; EG432451; 2310045H21Rik
Summary: Predicted to enable protein-macromolecule adaptor activity. Involved in heart contraction. Acts upstream of or within establishment of localization in cell; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; and response to bacterium. Predicted to be located in cytosol; nucleoplasm; and sarcoplasmic reticulum. Predicted to be part of calcium channel complex and junctional membrane complex. Predicted to be active in junctional sarcoplasmic reticulum membrane and plasma membrane. Is expressed in embryo and heart. Human ortholog(s) of this gene implicated in catecholaminergic polymorphic ventricular tachycardia and catecholaminergic polymorphic ventricular tachycardia 5. Orthologous to human TRDN (triadin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in heart adult (RPKM 10.6), mammary gland adult (RPKM 3.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 18.37 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (32959479..33352705)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (33083483..33476709)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.
Title: Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart.
Quantification of the calcium signaling deficit in muscles devoid of triadin.
Title: Quantification of the calcium signaling deficit in muscles devoid of triadin.
Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model.
Title: Association of decreased triadin expression level with apoptosis of dopaminergic cells in Parkinson's disease mouse model.
Dynamics of triadin, a muscle-specific triad protein, within sarcoplasmic reticulum subdomains.
Title: Dynamics of triadin, a muscle-specific triad protein, within sarcoplasmic reticulum subdomains.
The lncRNA TRDN-AS regulates the balance between cardiac and skeletal isoforms of triadin.
Title: A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin.
CLIMP-63 (also known as CKAP4), is the partner of triadin, is responsible for this association of triads and microtubules.
Title: Triadin and CLIMP-63 form a link between triads and microtubules in muscle cells.
The minimal KEKE motif of TRN involved in the interactions with CSQ2, HRC and RyR2 within the Ca2+ release units of cardiac sarcoplasmic reticulum has been defined.
Title: Characterization of Ca(2+)-Dependent Protein-Protein Interactions within the Ca(2+) Release Units of Cardiac Sarcoplasmic Reticulum.
Three regions in triadin are identified that mediate targeting to the junctional domain of sarcoplasmic reticulum.
Title: Distinct regions of triadin are required for targeting and retention at the junctional domain of the sarcoplasmic reticulum.
in skeletal muscle the disruption of Tdn/CASQ link has a more profound effect on jSR architecture and myoplasmic Ca(2+) regulation than Jct/CASQ association.
Title: Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.
The triadin-to-calsequestrin ratio is a critical modulator of the sarcoplasmic reticulum Ca(2+) signaling in ventricular myocytes.
Title: Modulation of SR Ca2+ release by the triadin-to-calsequestrin ratio in ventricular myocytes.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MPC1049 (e-PCR)
- UniSTS:125471

MHAa13b9.seq (e-PCR)
- UniSTS:125059

Trdn (e-PCR), detects polymorphism
- UniSTS:507353

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of junctional membrane complex	ISO Inferred from Sequence Orthology more info
is_active_in junctional sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in junctional sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: triadin

Names: cardiac triadin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.