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    Fsip1 fibrous sheath-interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 71313, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Fsip1provided by MGI
    Official Full Name
    fibrous sheath-interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1918563
    See related
    Ensembl:ENSMUSG00000027344 AllianceGenome:MGI:1918563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700012M13Rik; 4933432K11Rik
    Summary
    Acts upstream of or within several processes, including axoneme assembly; homeostasis of number of cells within a tissue; and vesicle organization. Is active in acrosomal vesicle; nucleus; and sperm head. Orthologous to human FSIP1 (fibrous sheath interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.2), CNS E18 (RPKM 0.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fsip1 in Genome Data Viewer
    Location:
    2 E5; 2 59.38 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (117960742..118087468, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118130261..118256987, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13986 Neighboring gene STARR-positive B cell enhancer mm9_chr2:117936762-117937062 Neighboring gene predicted gene, 25308 Neighboring gene thrombospondin 1 Neighboring gene STARR-seq mESC enhancer starr_05456 Neighboring gene STARR-positive B cell enhancer ABC_E7849 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118089004-118089305 Neighboring gene STARR-seq mESC enhancer starr_05457 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene STARR-seq mESC enhancer starr_05459 Neighboring gene G protein-coupled receptor 176 Neighboring gene STARR-positive B cell enhancer ABC_E1594 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic mutation in Fsip1 impairs acrosome vesicle formation and attenuates flagellogenesis in mice. Gamallat Y, et al. Redox Biol, 2021 Jul. PMID 33901807, Free PMC Article
    2. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Brown PR, et al. Biol Reprod, 2003 Jun. PMID 12606363
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single fertilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle budding from membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in motile cilium IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm head IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm head IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibrous sheath-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374672.1 → NP_001361601.1  fibrous sheath-interacting protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL845495
      Consensus CDS
      CCDS89537.1
      UniProtKB/TrEMBL
      A0A2R8W6Q5
      Related
      ENSMUSP00000155242.2, ENSMUST00000231133.2
      Conserved Domains (1) summary
      pfam15554
      Location:4 → 405
      FSIP1; FSIP1 family

    2. NM_027759.3 → NP_082035.1  fibrous sheath-interacting protein 1 isoform 2

      See identical proteins and their annotated locations for NP_082035.1

      Status: VALIDATED

      Source sequence(s)
      AK017026, AL845495
      Consensus CDS
      CCDS16573.1
      UniProtKB/Swiss-Prot
      Q8R4I9, Q9D3V5, Q9DAD8
      Related
      ENSMUSP00000028821.4, ENSMUST00000028821.10
      Conserved Domains (1) summary
      pfam15554
      Location:4 → 405
      FSIP1; FSIP1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      117960742..118087468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500175.2 → XP_006500238.1  fibrous sheath-interacting protein 1 isoform X1

      Conserved Domains (1) summary
      pfam15554
      Location:34 → 435
      FSIP1; FSIP1 family

    2. XM_006500176.3 → XP_006500239.1  fibrous sheath-interacting protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15554
      Location:34 → 434
      FSIP1; FSIP1 family

    3. XM_030252079.1 → XP_030107939.1  fibrous sheath-interacting protein 1 isoform X5

      Conserved Domains (1) summary
      pfam15554
      Location:4 → 404
      FSIP1; FSIP1 family

    4. XM_006500179.2 → XP_006500242.1  fibrous sheath-interacting protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15554
      Location:34 → 434
      FSIP1; FSIP1 family

    5. XM_006500178.2 → XP_006500241.1  fibrous sheath-interacting protein 1 isoform X3

      Conserved Domains (1) summary
      pfam15554
      Location:34 → 435
      FSIP1; FSIP1 family

    RNA

    1. XR_001783179.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3V5.1 GenPept UniProtKB/Swiss-Prot:Q9D3V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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