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    Or4k42 olfactory receptor family 4 subfamily K member 42 [ Mus musculus (house mouse) ]

    Gene ID: 257662, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or4k42provided by MGI
    Official Full Name
    olfactory receptor family 4 subfamily K member 42provided by MGI
    Primary source
    MGI:MGI:3031124
    See related
    Ensembl:ENSMUSG00000095809 AllianceGenome:MGI:3031124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOR248-9; Olfr1290
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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    Genomic context

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    See Or4k42 in Genome Data Viewer
    Location:
    2 E3; 2 56.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (111319563..111324160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (111489218..111493815, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily G member 7 Neighboring gene olfactory receptor family 4 subfamily F member 4B Neighboring gene olfactory receptor family 4 subfamily F member 4, pseudogene 1 Neighboring gene olfactory receptor family 4 subfamily K member 43, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. Favor J, et al. Genetics, 2009 Aug. PMID 19474196, Free PMC Article
    2. The chromosomal distribution of mouse odorant receptor genes. Sullivan SL, et al. Proc Natl Acad Sci U S A, 1996 Jan 23. PMID 8570653, Free PMC Article
    3. The olfactory receptor gene superfamily of the mouse. Zhang X, et al. Nat Neurosci, 2002 Feb. PMID 11802173
    4. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Young JM, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875048
    5. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels. Young JM, et al. Genome Biol, 2003. PMID 14611657, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of smell ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    olfactory receptor 1290

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278787.1 → NP_001265716.1  olfactory receptor 1290

      See identical proteins and their annotated locations for NP_001265716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AL731699
      Consensus CDS
      CCDS50659.1
      UniProtKB/TrEMBL
      Q7TQX8, Q8K4Z8
      Related
      ENSMUSP00000150388.2, ENSMUST00000217611.2
      Conserved Domains (1) summary
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    2. NM_001278788.1 → NP_001265717.1  olfactory receptor 1290

      See identical proteins and their annotated locations for NP_001265717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AL731699
      Consensus CDS
      CCDS50659.1
      UniProtKB/TrEMBL
      Q7TQX8, Q8K4Z8
      Related
      ENSMUSP00000097211.2, ENSMUST00000099616.2
      Conserved Domains (1) summary
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    3. NM_146262.3 → NP_666374.2  olfactory receptor 1290

      See identical proteins and their annotated locations for NP_666374.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3, encode the same protein.
      Source sequence(s)
      AL731699
      Consensus CDS
      CCDS50659.1
      UniProtKB/TrEMBL
      Q7TQX8, Q8K4Z8
      Conserved Domains (1) summary
      cl21561
      Location:31 → 304
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      111319563..111324160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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