Nr2c2 nuclear receptor subfamily 2, group C, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nr2c2provided by MGI
Official Full Name: nuclear receptor subfamily 2, group C, member 2provided by MGI
Primary source: MGI:MGI:1352466
See related: Ensembl:ENSMUSG00000005893 AllianceGenome:MGI:1352466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tr4; TAK1; mKIAA4145
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Involved in several processes, including p38MAPK cascade; positive regulation of embryonic development; and positive regulation of myoblast differentiation. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; meiotic cell cycle; and spermatogenesis. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NR2C2 (nuclear receptor subfamily 2 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 13.2), thymus adult (RPKM 12.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 41.03 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (92068426..92150039)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (92091418..92173058)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
Title: Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
Title: Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
Title: Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
TR4 worsen urosepsis by regulating GSDMD.
Title: TR4 worsen urosepsis by regulating GSDMD.
TAK1 is an essential kinase for STING trafficking.
Title: TAK1 is an essential kinase for STING trafficking.
Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
Title: Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
Transforming Growth Factor-beta-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
Title: Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
Title: p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Title: Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
Title: Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nr2c2 (e-PCR), detects polymorphism
- UniSTS:144665

36.MMHAP88FLD6.seq (e-PCR)
- UniSTS:124199

NR2C2_2354 (e-PCR)
- UniSTS:280875

Clone Names

KIAA4145, MGC124356, MGC124357, MGC124358

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of embryonic development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor subfamily 2 group C member 2

Names: nuclear receptor subfamily 2, group H, member 2; orphan nuclear receptor TAK1; orphan nuclear receptor TR4; orphan receptor, TR4; testicular receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347342.2 → NP_001334271.1 nuclear receptor subfamily 2 group C member 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).

Source sequence(s)

AC121593, AC164642

Consensus CDS

CCDS85096.1

UniProtKB/TrEMBL

G3X9W4, Q3U015

Related

ENSMUSP00000109090.2, ENSMUST00000113463.8

Conserved Domains (2) summary

cd06952
Location:394 → 615

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:145 → 231

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_001410478.1 → NP_001397407.1 nuclear receptor subfamily 2 group C member 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121593, AC164642

UniProtKB/TrEMBL

G3X9W4
NM_001410479.1 → NP_001397408.1 nuclear receptor subfamily 2 group C member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121593, AC164642

UniProtKB/Swiss-Prot

P49117, P55093

UniProtKB/TrEMBL

Q3ZAS1
NM_001410480.1 → NP_001397409.1 nuclear receptor subfamily 2 group C member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121593, AC164642

UniProtKB/Swiss-Prot

P49117, P55093

UniProtKB/TrEMBL

Q3ZAS1

Related

ENSMUSP00000138465.2, ENSMUST00000146175.2
NM_001410481.1 → NP_001397410.1 nuclear receptor subfamily 2 group C member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121593, AC164642

UniProtKB/Swiss-Prot

P49117, P55093

UniProtKB/TrEMBL

Q3ZAS1
NM_001410482.1 → NP_001397411.1 nuclear receptor subfamily 2 group C member 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121593, AC164642

UniProtKB/Swiss-Prot

P49117, P55093

UniProtKB/TrEMBL

Q3ZAS1
NM_001410483.1 → NP_001397412.1 nuclear receptor subfamily 2 group C member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121593, AC164642
NM_001410484.1 → NP_001397413.1 nuclear receptor subfamily 2 group C member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121593, AC164642
NM_001410485.1 → NP_001397414.1 nuclear receptor subfamily 2 group C member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121593, AC164642
NM_011630.4 → NP_035760.1 nuclear receptor subfamily 2 group C member 2 isoform 2

See identical proteins and their annotated locations for NP_035760.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus, compared to isoform 1. Variants 2 and 4-7 all encode the same isoform (2).

Source sequence(s)

AC121593, AC164642

Consensus CDS

CCDS20372.1

UniProtKB/Swiss-Prot

P49117, P55093

UniProtKB/TrEMBL

Q3U015, Q3ZAS1

Related

ENSMUSP00000109087.2, ENSMUST00000113460.8

Conserved Domains (2) summary

cd06952
Location:361 → 582

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:112 → 198

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

92068426..92150039

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321518.1 → XP_017177007.1 nuclear receptor subfamily 2 group C member 2 isoform X3

UniProtKB/TrEMBL

Q5DTL3

Conserved Domains (2) summary

cd06952
Location:182 → 403

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cl02596
Location:1 → 19

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers