Ptpn13 protein tyrosine phosphatase, non-receptor type 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpn13provided by MGI
Official Full Name: protein tyrosine phosphatase, non-receptor type 13provided by MGI
Primary source: MGI:MGI:103293
See related: Ensembl:ENSMUSG00000034573 AllianceGenome:MGI:103293
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIP; PTPL1; Ptpri; PTP-BL
Summary: Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of excitatory synapse assembly; peptidyl-tyrosine dephosphorylation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including brain; epithelium; genitourinary system; gut; and humerus cartilage condensation. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and colorectal cancer (multiple). Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 15.0), ovary adult (RPKM 11.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.43 cM

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (103573058..103746227)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (103425192..103598361)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy.
Title: Co-delivery of siPTPN13 and siNOX4 via (myo)fibroblast-targeting polymeric micelles for idiopathic pulmonary fibrosis therapy.
Both in its ligand-free state and when bind to PRK2, PDZ3 of PTPN13 adopts the classical compact, globular D/E fold. PDZ3 of PTPN13 binds five carboxy-terminal amino acids of PRK2 via a groove located between the EB-strand and the DB-helix.
Title: Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.
Following TBI, calpain-2 activation cleaved PTPN13, activated c-Abl and triggered tau tyrosine phosphorylation.
Title: The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.
contributions of Fap1 to tyrosine kinase inhibitors (TKI)resistance, CML blast crisis, and relapse after TKI discontinuation
Title: The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia.
The data show that the levels of PTPN13 and beta-catenin must be strictly regulated by extracellular signaling to regulate hematopoietic stem cells attachment to the bone marrow niche and the balance between proliferation and quiescence.
Title: PTPN13 and β-Catenin Regulate the Quiescence of Hematopoietic Stem Cells and Their Interaction with the Bone Marrow Niche.
The study presents a detailed kinetics analysis of the interaction between PTP-BL PDZ2 domain and a peptide mimicking the PDZ binding motif of APC.
Title: The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor.
SDCCAG3 forms a complex with PTPN13. Interaction of SDCCAG3 with PTPN13 is mediated via the FERM domain of PTPN13 and via the N-terminus of SDCCAG3.
Title: The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.
Data indicate that Bcr-abl increases PTPN13 promoter activity in an Icsbp-dependent manner.
Title: Fas-associated phosphatase 1 mediates Fas resistance in myeloid progenitor cells expressing the Bcr-abl oncogene.
Since PTPL1 catalytic activity is important for cell transformation, VCP regulation by PTPL1 might be important for tumorigenesis.
Title: Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.
These findings demonstrate a key role for PTP-BL in 3T3-L1 and mouse embryo fibroblasts-derived adipocyte differentiation that is independent of its enzymatic activity.
Title: Downregulation of protein tyrosine phosphatase PTP-BL represses adipogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptpn13 (e-PCR), detects polymorphism
- UniSTS:498440

AI324989 (e-PCR)
- UniSTS:179213

07.MMHAP57FRC7.seq (e-PCR)
- UniSTS:122893

SHGC-67903 (e-PCR)
- UniSTS:41756

Z32740 (e-PCR)
- UniSTS:185634

D5Mit93 (e-PCR), detects polymorphism
- UniSTS:130635

10.MHAa98e10.seq (e-PCR)
- UniSTS:123014

NoName (e-PCR)
- UniSTS:235239

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of excitatory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 13

Names: PTP36; protein tyrosine phosphatase DPZPTP; protein tyrosine phosphatase PTP-BL; protein-tyrosine phosphatase RIP; tyrosine phosphatase

NP_035334.2

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011204.2 → NP_035334.2 tyrosine-protein phosphatase non-receptor type 13

See identical proteins and their annotated locations for NP_035334.2

Status: VALIDATED

Source sequence(s)

AK014577, AK080313, AK161200, AK164471, CF553324, CK391553, CX202144, Z32740

Consensus CDS

CCDS39186.1

UniProtKB/Swiss-Prot

Q61494, Q62135, Q64499, Q64512

UniProtKB/TrEMBL

G5E8B1

Related

ENSMUSP00000048119.10, ENSMUST00000048957.11

Conserved Domains (11) summary

smart00194
Location:2181 → 2433

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00228
Location:1488 → 1578

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

smart00295
Location:566 → 774

B41; Band 4.1 homologues

smart00750
Location:3 → 190

KIND; kinase non-catalytic C-lobe domain

cd00047
Location:2207 → 2433

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:1082 → 1166

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00373
Location:661 → 774

FERM_M; FERM central domain

pfam06614
Location:2067 → 2207

Neuromodulin; Neuromodulin

pfam09379
Location:569 → 631

FERM_N; FERM N-terminal domain

pfam16599
Location:1168 → 1356

PTN13_u3; Unstructured linker region on PTN13 protein between PDZ

cl17171
Location:770 → 870

PH-like; Pleckstrin homology-like domain