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    SDH8 Sdh8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDH8
    Official Full Name
    Sdh8p
    Primary source
    SGD:S000000473
    Locus tag
    YBR269C
    See related
    AllianceGenome:SGD:S000000473; FungiDB:YBR269C; VEuPathDB:YBR269C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FMP21
    Summary
    Enables protein folding chaperone. Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrial matrix. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDH8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (742160..742576, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rei1p Neighboring gene Slm6p Neighboring gene mitochondrial 54S ribosomal protein YmL37 Neighboring gene Bit2p Neighboring gene S-adenosylmethionine-dependent methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene, FMP21, whose expression levels are involved in thermotolerance in Saccharomyces cerevisiae. Nakamura T, et al. AMB Express, 2014. PMID 25177541, Free PMC Article
    2. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498
    3. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Van Vranken JG, et al. Cell Metab, 2014 Aug 5. PMID 24954416, Free PMC Article
    4. Insight into the Antioxidant Effect of Fermented and Non-Fermented Spirulina Water and Ethanol Extracts at the Proteome Level Using a Yeast Cell Model. Masten Rutar J, et al. Antioxidants (Basel), 2021 Aug 27. PMID 34572998, Free PMC Article
    5. Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker. Makepeace KAT, et al. Mol Cell Proteomics, 2020 Apr. PMID 32051233, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein folding chaperone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sdh8p
    NP_009828.2
    • Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      742160..742576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178617.1 → NP_009828.2  TPA: Sdh8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009828.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQR5, P38345
      UniProtKB/TrEMBL
      A6ZLK8, B3LMP3, C7GMW2, D3UF17, G2W9S3, N1P773
      Conserved Domains (1) summary
      pfam07896
      Location:103 → 138
      DUF1674; Protein of unknown function (DUF1674)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38345.2

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