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    PDR12 ATP-binding cassette multidrug transporter PDR12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDR12
    Official Full Name
    ATP-binding cassette multidrug transporter PDR12
    Primary source
    SGD:S000005979
    Locus tag
    YPL058C
    See related
    AllianceGenome:SGD:S000005979; FungiDB:YPL058C; VEuPathDB:YPL058C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables organic acid transmembrane transporter activity. Involved in organic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDR12 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (445842..450377, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene monothiol glutaredoxin GRX5 Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 Neighboring gene Lcl1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism. Holyoak CD, et al. J Bacteriol, 1999 Aug. PMID 10419965, Free PMC Article
    2. A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism. Hazelwood LA, et al. FEMS Yeast Res, 2006 Sep. PMID 16911515
    3. [Acid stress increases the activity of superoxide dismutase and catalase in the yeast Saccharomyces cerevisiae]. Abrat OB, et al. Ukr Biokhim Zh (1999), 2007 Mar-Apr. PMID 18030745
    4. Pdr12p-dependent and -independent fluorescein extrusion from baker's yeast cells. Lushchak V, et al. Acta Biochim Pol, 2008. PMID 18800175
    5. Transcriptional expression of selected genes associated with excretion of carboxylic acids from aci mutants of Saccharomyces cerevisiae. Boniewska-Bernacka E, et al. Postepy Hig Med Dosw (Online), 2013 Apr 29. PMID 23667093

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of PDR12 increased tolerance to acids with longer chain length, such as sorbic, propionic and levulinic acid, whereas deletion of PDR12 increased tolerance to the shorter acetic and formic acid.
      Title: The diverse role of Pdr12 in resistance to weak organic acids.
    2. These results indicate that the induction of the two cell transporter genes(Pdr12 and PMA1) plays an important role in acid excretion by the aci mutants of Saccharomyces cerevisiae.
      Title: Transcriptional expression of selected genes associated with excretion of carboxylic acids from aci mutants of Saccharomyces cerevisiae.
    3. membrane protein Pdr12 is involved in fluorescein extrusion, but component(s) other than Pdr12p is (are) also important.
      Title: Pdr12p-dependent and -independent fluorescein extrusion from baker's yeast cells.
    4. findings indicate that Pdr12p is involved in export of the fusel acids, but not the fusel alcohols derived from leucine, isoleucine, valine, phenylalanine and tryptophan.
      Title: A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in organic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette multidrug transporter PDR12
    NP_015267.1
    • Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      445842..450377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183872.1 → NP_015267.1  TPA: ATP-binding cassette multidrug transporter PDR12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3V6, Q02785
      UniProtKB/TrEMBL
      C7GTZ8, N1P1Q8
      Conserved Domains (1) summary
      TIGR00956
      Location:89 → 1468
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02785.1

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