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    Fbp2 Fat body protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbp2provided by FlyBase
    Official Full Name
    Fat body protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0000640
    Locus tag
    Dmel_CG3763
    See related
    AllianceGenome:FB:FBgn0000640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3763; Dmel\CG3763; Fbp-2; FBP2; P6; T19
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in cytoplasm. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fbp2 in Genome Data Viewer
    Location:
    30B3-30B3; 2-35 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9426784..9427917)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9426784..9427917)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Shaw-like Neighboring gene uncharacterized protein Neighboring gene Multicopper oxidase 1 Neighboring gene uncharacterized protein Neighboring gene alpha1,3-fucosyltransferase B Neighboring gene scattered

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunological method for mapping genes on Drosophila polytene chromosomes. Langer-Safer PR, et al. Proc Natl Acad Sci U S A, 1982 Jul. PMID 6812046, Free PMC Article
    2. Molecular variation of Adh and P6 genes in an African population of Drosophila melanogaster and its relation to chromosomal inversions. Bénassi V, et al. Genetics, 1993 Jul. PMID 8349110, Free PMC Article
    3. Partial sweeping of variation at the Fbp2 locus in a west African population of Drosophila melanogaster. Bénassi V, et al. Mol Biol Evol, 1999 Mar. PMID 10331261
    4. Drosophila fat body protein P6 and alcohol dehydrogenase are derived from a common ancestral protein. Rat L, et al. J Mol Evol, 1991 Aug. PMID 1920455
    5. Histochemical analysis of the ecdysterone-regulated expression of the Drosophila genes P1 and LSP-2. Paco-Larson ML, et al. Dev Genet, 1986. PMID 3453783

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nutrient reservoir activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fat body protein 2
    Names
    CG3763-PA
    CG3763-PB
    CG3763-PC
    Fbp2-PA
    Fbp2-PB
    Fbp2-PC
    Protein-6
    fat body protein P6
    NP_001285777.1
    NP_001285778.1
    NP_523522.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9426784..9427917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298848.1 → NP_001285777.1  Fat body protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285777.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61511, O61512, O61513, O61514, O62595, P54398, Q9VLC2
      UniProtKB/TrEMBL
      X2J986
      Conserved Domains (2) summary
      cd05323
      Location:7 → 249
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 198
      adh_short; short chain dehydrogenase

    2. NM_078798.4 → NP_523522.1  Fat body protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61511, O61512, O61513, O61514, O62595, P54398, Q9VLC2
      UniProtKB/TrEMBL
      X2J986
      Related
      FBpp0079408
      Conserved Domains (2) summary
      cd05323
      Location:7 → 249
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 198
      adh_short; short chain dehydrogenase

    3. NM_001298849.1 → NP_001285778.1  Fat body protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61511, O61512, O61513, O61514, O62595, P54398, Q9VLC2
      UniProtKB/TrEMBL
      X2J986
      Conserved Domains (2) summary
      cd05323
      Location:7 → 249
      ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
      pfam00106
      Location:7 → 198
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54398.2 P54398
    X2J986 X2J986

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