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    Es2 Es2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31780, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Es2provided by FlyBase
    Official Full Name
    Es2provided by FlyBase
    Primary source
    FLYBASE:FBgn0023506
    Locus tag
    Dmel_CG1474
    See related
    AllianceGenome:FB:FBgn0023506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1474; Dmel\CG1474; es; ES2
    Summary
    Predicted to be involved in nervous system development. Part of catalytic step 2 spliceosome. Orthologous to human ESS2 (ess-2 splicing factor homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Es2 in Genome Data Viewer
    Location:
    7E11-7E11; 1-23 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8461479..8463349)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8355512..8357382)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sepiapterin reductase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chorion protein a at 7F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ES2, a gene deleted in DiGeorge syndrome, encodes a nuclear protein and is expressed during early mouse development, where it shares an expression domain with a Goosecoid-like gene. Lindsay EA, et al. Hum Mol Genet, 1998 Apr. PMID 9499415
    2. Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Claycomb JM, et al. Dev Cell, 2004 Jan. PMID 14723854
    3. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
    4. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874
    5. Chromosomal rearrangement inferred from comparisons of 12 Drosophila genomes. Bhutkar A, et al. Genetics, 2008 Jul. PMID 18622036, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Es2
    Names
    CG1474-PA
    Es2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8461479..8463349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132252.5 → NP_572480.1  Es2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44424, Q8T9F3, Q9W3F2
      UniProtKB/TrEMBL
      B5RIV5
      Related
      FBpp0071145
      Conserved Domains (1) summary
      pfam09751
      Location:47 → 417
      Es2; Nuclear protein Es2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44424.2 O44424

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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