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    CG10254 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10254provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027512
    Locus tag
    Dmel_CG10254
    See related
    AllianceGenome:FB:FBgn0027512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD22087; Dmel\CG10254
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein monoubiquitination and retrograde transport, endosome to Golgi. Predicted to be located in cytoplasm. Is expressed in adult head and organism. Orthologous to human UBE2O (ubiquitin conjugating enzyme E2 O). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10254 in Genome Data Viewer
    Location:
    95A7-95A7; 3-80 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23689007..23694983, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19514729..19520705, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spatzle-Processing Enzyme Neighboring gene antisense RNA:CR43903 Neighboring gene uncharacterized protein Neighboring gene portabella

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Wong SL, et al. Biochem Biophys Res Commun, 2005 Nov 18. PMID 16212942, Free PMC Article
    2. A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. Pauli A, et al. Curr Biol, 2010 Oct 26. PMID 20933422, Free PMC Article
    3. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article
    4. C9orf72 arginine-rich dipeptide proteins interact with ribosomal proteins in vivo to induce a toxic translational arrest that is rescued by eIF1A. Moens TG, et al. Acta Neuropathol, 2019 Mar. PMID 30604225, Free PMC Article
    5. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Lee KH, et al. Cell, 2016 Oct 20. PMID 27768896, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10254-PA
    CG10254-PB
    CG10254-PC
    NP_001262878.1
    NP_651170.1
    NP_732888.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23689007..23694983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170081.2 → NP_732888.1  uncharacterized protein Dmel_CG10254, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ32
      Related
      FBpp0083867
      Conserved Domains (1) summary
      pfam00179
      Location:1126 → 1272
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001275949.1 → NP_001262878.1  uncharacterized protein Dmel_CG10254, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHY8
      Conserved Domains (1) summary
      pfam00179
      Location:1107 → 1253
      UQ_con; Ubiquitin-conjugating enzyme

    3. NM_142913.2 → NP_651170.1  uncharacterized protein Dmel_CG10254, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651170.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ32
      Related
      FBpp0083868
      Conserved Domains (1) summary
      pfam00179
      Location:1126 → 1272
      UQ_con; Ubiquitin-conjugating enzyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHY8 A0A0B4KHY8
    Q9XZ32 Q9XZ32

    Gene LinkOut

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