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    Nepl15 Neprilysin-like 15 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42701, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl15provided by FlyBase
    Official Full Name
    Neprilysin-like 15provided by FlyBase
    Primary source
    FLYBASE:FBgn0039024
    Locus tag
    Dmel_CG4721
    See related
    AllianceGenome:FB:FBgn0039024
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey132; CG4721; Dmel\CG4721
    Summary
    Involved in compound eye morphogenesis. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic ventral epidermis; epidermis; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl15 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22763960..22766172, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18589682..18591894, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ubiquitin-specific protease 12/46 Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 13 Neighboring gene Neprilysin-like 14 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila melanogaster Neprilysin Nepl15 is involved in lipid and carbohydrate storage. Banerjee S, et al. Sci Rep, 2021 Jan 22. PMID 33483521, Free PMC Article
    2. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
    3. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    4. Identifying sleep regulatory genes using a Drosophila model of insomnia. Seugnet L, et al. J Neurosci, 2009 Jun 3. PMID 19494137, Free PMC Article
    5. Analysis of the transcriptomes downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch signaling pathways in Drosophila melanogaster. Nfonsam LE, et al. PLoS One, 2012. PMID 22952997, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 15
    Names
    CG4721-PA
    Nepl15-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22763960..22766172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142841.4 → NP_651098.2  Neprilysin-like 15 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651098.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U74, Q9VCU1
      Related
      FBpp0083710
      Conserved Domains (2) summary
      cd08662
      Location:57 → 684
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:57 → 677
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95U74 Q95U74
    Q9VCU1 Q9VCU1

    Gene LinkOut

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