U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AhcyL1 Adenosylhomocysteinase like 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38342, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AhcyL1provided by FlyBase
    Official Full Name
    Adenosylhomocysteinase like 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0035371
    Locus tag
    Dmel_CG9977
    See related
    AllianceGenome:FB:FBgn0035371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9977; dAhcyL1; Dmel\CG9977; IRBIT
    Summary
    Involved in S-adenosylhomocysteine catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut; ganglia; and larval glial cell. Orthologous to human AHCYL1 (adenosylhomocysteinase like 1) and AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AhcyL1 in Genome Data Viewer
    Location:
    62F3-62F3; 3-4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (2768466..2772325, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (2768466..2772325, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Myocardin-related transcription factor Neighboring gene Accessory gland protein 62F Neighboring gene Novel nucleolar protein 2 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. IRBIT Directs Differentiation of Intestinal Stem Cell Progeny to Maintain Tissue Homeostasis. Arnaoutov A, et al. iScience, 2020 Mar 27. PMID 32179478, Free PMC Article
    2. Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform. Pun FW, et al. Front Aging Neurosci, 2022. PMID 35837482, Free PMC Article
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. Ageing, metabolism and the intestine. Funk MC, et al. EMBO Rep, 2020 Jul 3. PMID 32567155, Free PMC Article
    5. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables adenosylhomocysteinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    adenosylhomocysteinase like 1
    Names
    AhcyL1-PA
    CG9977-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      2768466..2772325 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139489.2 → NP_647746.1  adenosylhomocysteinase like 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NR07, Q9VZX9
      Related
      FBpp0072886
      Conserved Domains (1) summary
      pfam05221
      Location:94 → 520
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZX9.1 Q9VZX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous