Ac3 Adenylate cyclase 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ac3provided by FlyBase
Official Full Name: Adenylate cyclase 3provided by FlyBase
Primary source: FLYBASE:FBgn0023416
Locus tag: Dmel_CG1506
See related: AllianceGenome:FB:FBgn0023416
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC 3; ac3; AC3; CG1506; DAC3; DAC39E; dADCY3; Dmel\CG1506
Summary: Enables adenylate cyclase activity. Involved in locomotor rhythm. Predicted to be active in plasma membrane. Is expressed in adult brain; adult head; adult optic lobe neurons; antenna; and gnathal ganglion. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 39E3-39E3; 2-54 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (21632587..21647964)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (21632587..21647964)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flies with AC3 alterations show behavioral syndromes consistent with known roles of M pacemakers as mediated by PDF
Title: The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 21644393-21644993 mobile_element_type = transposon:INE-1{}4741
Loc: 21644994-21645053 mobile_element_type = transposon:FB{}4835
Loc: 21646497-21646546 mobile_element_type = transposon:INE-1{}4742

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase 3

Names: Ac3-PA; Ac3-PC; CG1506-PA; CG1506-PC

NP_001014496.1

EC 4.6.-.-

EC 4.6.1.1

NP_610116.2

EC 4.6.-.-

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

21632587..21647964

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136272.3 → NP_610116.2 adenylate cyclase 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610116.2

Status: REVIEWED

UniProtKB/TrEMBL

O96306, Q9V9R3

Related

FBpp0085252

Conserved Domains (3) summary

smart00044
Location:256 → 453

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:892 → 1092

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:127 → 285

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001014496.3 → NP_001014496.1 adenylate cyclase 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014496.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RI9

Conserved Domains (1) summary

pfam16214
Location:127 → 285

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region