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    Ubi-p63E Ubiquitin-63E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38456, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubi-p63Eprovided by FlyBase
    Official Full Name
    Ubiquitin-63Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003943
    Locus tag
    Dmel_CG11624
    See related
    AllianceGenome:FB:FBgn0003943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11624; Dmel\CG11624; DmUb; DmUbi-p63E; magn; Ub; UB; Ub-p63E; ubi; Ubi-p; ubi-p63E; Ubi-P63e; ubi63E; Ubi63E; Ubi63p; Ubip; Ubip63E; Ubiq; Ubp
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in larval midgut cell programmed cell death and macroautophagy. Predicted to be active in cytoplasm and nucleus. Is expressed in spermatocyte. Orthologous to human UBC (ubiquitin C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ubi-p63E in Genome Data Viewer
    Location:
    63F5-63F5; 3-9 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3899259..3903184, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3899259..3903184, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 63a Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene Caffeine, calcium, zinc sensitivity 1 Neighboring gene Sc2 Neighboring gene imaginal discs arrested

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Localization and expression of transformed DNA sequences within heat shock puffs of Drosophila melanogaster. Simon JA, et al. Chromosoma, 1985. PMID 3933923
    2. Puffing patterns in Drosophila melanogaster and related species. Ashburner M. Results Probl Cell Differ, 1972. PMID 4198830
    3. Cloning and characterization of nine heat-shock-induced mRNAs of Drosophila melanogaster. Lis JT, et al. Gene, 1981 Oct. PMID 6795091
    4. Polyubiquitin-regulated DsRed marker for transgenic insects. Handler AM, et al. Biotechniques, 2001 Oct. PMID 11680713
    5. Distinct responses to rare codons in select Drosophila tissues. Allen SR, et al. Elife, 2022 May 6. PMID 35522036, Free PMC Article

    See all (332) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results showed the molecular cloning UB and L40 genes from Drosophila kc cells and the first evidence that both of them play roles in the regulation of deltamethrin resistance.
      Title: Analysis of UB and L40 resistance related to deltamethrin in Drosophila kc cells.
    2. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila.
      Title: The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila.
    3. Ubiquitylation of p54
      Title: Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-63E
    Names
    CG11624-PA
    CG11624-PB
    CG11624-PC
    CG11624-PD
    Ubi-p63E-PA
    Ubi-p63E-PB
    Ubi-p63E-PC
    Ubi-p63E-PD
    Ubiquitin-63-E
    Ubiquitin-polymeric
    magellan
    polyubiquitin
    ubiquitin
    ubiquitin 63E
    ubiquitin-63E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3899259..3903184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079185.4 → NP_523909.2  Ubiquitin-63E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523909.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0CG69
      UniProtKB/TrEMBL
      A4V1F9
      Related
      FBpp0073035, FBtr0073178
      Conserved Domains (1) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

    2. NM_001274454.1 → NP_001261383.1  Ubiquitin-63E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261383.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0CG69
      UniProtKB/TrEMBL
      A4V1F9
      Conserved Domains (1) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

    3. NM_206272.1 → NP_995994.1  Ubiquitin-63E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0CG69
      UniProtKB/TrEMBL
      A4V1F9
      Conserved Domains (1) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin

    4. NM_168043.3 → NP_728908.1  Ubiquitin-63E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0CG69
      UniProtKB/TrEMBL
      A4V1F9
      Related
      FBpp0073034
      Conserved Domains (1) summary
      cd01803
      Location:77 → 152
      Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V1F9 A4V1F9
    P0CG69.1 P0CG69
    Q24575 Q24575
    Q24576 Q24576
    Q24577 Q24577
    Q27927 Q27927
    Q7JPZ2 Q7JPZ2
    Q7JPZ3 Q7JPZ3
    Q8MSM5 Q8MSM5
    Q99347 Q99347
    Q99348 Q99348
    Q99349 Q99349
    Q99350 Q99350
    Q99351 Q99351

    Gene LinkOut

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