fs(1)h female sterile (1) homeotic [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fs(1)hprovided by FlyBase
Official Full Name: female sterile (1) homeoticprovided by FlyBase
Primary source: FLYBASE:FBgn0004656
Locus tag: Dmel_CG2252
See related: AllianceGenome:FB:FBgn0004656
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe1G2; anon-EST:Liang-1.81; Brd4; CG2252; clone 1.81; dBRD4; Dmel\CG2252; fs(1)1456; fs(1)26/26A; Fs(1)h; Fs(1)h-L; Fs(1)h/Brd4; Fs(1)hL; Fs(1)hS; fs(1)M16; fs(1)R10.4; fsh; Fsh; FSH; FSH-S; fst(1)h; fs[1]h; l(1)7Da; l(1)G0093; l(1)G0495; N72; ORE-1; rnc
Summary: Enables several functions, including DNA-binding transcription activator activity; P-TEFb complex binding activity; and lysine-acetylated histone binding activity. Involved in dendrite morphogenesis; regulation of DNA-templated transcription; and terminal region determination. Located in nucleus. Is expressed in several structures, including central brain primordium; embryonic/larval midgut; embryonic/larval midgut primordium; ganglia; and larval nervous system. Human ortholog(s) of this gene implicated in several diseases, including Cornelia de Lange syndrome 6; idiopathic pulmonary fibrosis; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to several human genes including BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7D3-7D5; 1-22 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8037808..8061436, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (7931841..7955469, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flies lacking fat body fs(1)h exhibit short lifespan, increased expression of immune target genes, an inability to metabolize triglyceride, and low basal AKT activity, mostly resulting from systemic defects in insulin signalling.
Title: fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila.
Consistent with the independent modes of CncC regulation by Keap1 and Fs(1)h, combinations of drugs that can specifically target these pathways cause a strong synergistic and specific activation of protective CncC- dependent gene expression and boosts oxidative stress resistance.
Title: Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.
Inhibition of FSH-binding to chromatin resulted in global down-regulation of transcription. FSH biochemically interacts with ASH1.
Title: The BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila.
The results indicate that the two Fs(1)h isoforms have different binding profiles, with the short isoform binding at promoters and enhancers.
Title: Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites.
data link Ras signaling with modulation of a chromatin-binding transcription factor, Fs(1)h, suggesting a novel mechanism by which Ras can modulate gene expression
Title: Drosophila female sterile (1) homeotic is a multifunctional transcriptional regulator that is modulated by Ras signaling.
the small isoform of fs(1)h acts as a critical component of a regulatory circuitry mediating long-range effects of distant enhancers.
Title: A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables P-TEFb complex binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in terminal region determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: female sterile (1) homeotic

Names: CG2252-PA; CG2252-PB; CG2252-PC; CG2252-PD; CG2252-PE; CG2252-PF; CG2252-PG; CG2252-PH; CG2252-PI; anon-fast-evolving-1G2; female sterile (1) homoeotic; female sterile 1 homeotic; female sterile homeotic; fs(1)h-PA; fs(1)h-PB; fs(1)h-PC; fs(1)h-PD; fs(1)h-PE; fs(1)h-PF; fs(1)h-PG; fs(1)h-PH; fs(1)h-PI; rancor

NP_001162699.1

EC 2.7.11.1

NP_001259321.1

EC 2.7.11.1

NP_001259322.1

EC 2.7.11.1

NP_001259323.1

EC 2.7.11.1

NP_511078.2

EC 2.7.11.1

NP_727228.1

EC 2.7.11.1

NP_996368.1

EC 2.7.11.1

NP_996369.1

EC 2.7.11.1

NP_996370.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8037808..8061436 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272392.2 → NP_001259321.1 female sterile (1) homeotic, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259321.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJC7

Conserved Domains (5) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:2026 → 2046

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_078523.3 → NP_511078.2 female sterile (1) homeotic, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511078.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V442, P13709, P13710, Q8IRN6, Q9W3L3

Related

FBpp0071074

Conserved Domains (5) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:2018 → 2038

BRD4_CDT; C-terminal domain of bromodomain protein 4
NM_206647.3 → NP_996370.1 female sterile (1) homeotic, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996370.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJJ8

Conserved Domains (4) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation
NM_167144.4 → NP_727228.1 female sterile (1) homeotic, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727228.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJJ8

Related

FBpp0071073

Conserved Domains (4) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation
NM_206646.4 → NP_996369.1 female sterile (1) homeotic, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996369.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJJ8

Conserved Domains (4) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation
NM_001272394.2 → NP_001259323.1 female sterile (1) homeotic, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259323.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGM8

Conserved Domains (3) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:486 → 586

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:956 → 1020

BET; Bromodomain extra-terminal - transcription regulation
NM_206645.4 → NP_996368.1 female sterile (1) homeotic, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996368.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJJ8

Conserved Domains (4) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation
NM_001272393.2 → NP_001259322.1 female sterile (1) homeotic, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259322.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PE02

Conserved Domains (3) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:476 → 576

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:946 → 1010

BET; Bromodomain extra-terminal - transcription regulation
NM_001169228.2 → NP_001162699.1 female sterile (1) homeotic, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162699.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJJ8

Conserved Domains (4) summary

cd05497
Location:34 → 140

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:481 → 581

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

COG5076
Location:387 → 593

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam17035
Location:951 → 1015

BET; Bromodomain extra-terminal - transcription regulation