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    byn brachyenteron [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39349, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bynprovided by FlyBase
    Official Full Name
    brachyenteronprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011723
    Locus tag
    Dmel_CG7260
    See related
    AllianceGenome:FB:FBgn0011723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    apro; Bra; Byn; byn/apro; CG7260; D-TRA; D-Trg; Dm-BYN; dm-Trg; Dmel\CG7260; DTrg; Tra; trg; Trg
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and protein homodimerization activity. Involved in Malpighian tubule morphogenesis; midgut development; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including amnioproctodeal invagination; embryonic small intestine; gut section; hindgut anlage; and hindgut anlage in statu nascendi. Human ortholog(s) of this gene implicated in adrenocorticotropic hormone deficiency; alcohol dependence; inherited metabolic disorder; and neural tube defect. Orthologous to several human genes including TBX19 (T-box transcription factor 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See byn in Genome Data Viewer
    Location:
    68E3-68E3; 3-37 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11927693..11935919)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11920793..11929019)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein)-like Neighboring gene uncharacterized protein Neighboring gene Regulatory particle triple-A ATPase 4-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of Brachyury proteins: identification of a novel regulatory domain conserved within Bilateria. Marcellini S, et al. Dev Biol, 2003 Aug 15. PMID 12921737
    2. Novel tissue units of regional differentiation in the gut epithelium of Drosopbila, as revealed by P-element-mediated detection of enhancer. Murakami R, et al. Rouxs Arch Dev Biol, 1994 Mar. PMID 28305621
    3. When Brachyury meets Smad1: the evolution of bilateral symmetry during gastrulation. Marcellini S. Bioessays, 2006 Apr. PMID 16547957
    4. Optomotor-blind in the development of the Drosophila HS and VS lobula plate tangential cells. Sen A, et al. J Neurogenet, 2014 Sep-Dec. PMID 24912380
    5. The homeodomain transcription factor Orthopedia is involved in development of the Drosophila hindgut. Hildebrandt K, et al. Hereditas, 2020 Nov 19. PMID 33213520, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brachyenteron activates the homeobox gene orthopedia in a dose-dependent manner via multiple consensus binding sites.
      Title: Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in heart morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hindgut morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mesoderm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mesoderm migration involved in gastrulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in midgut development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    brachyenteron
    Names
    CG7260-PB
    CG7260-PC
    T related antigen
    T-related gene
    aproctous
    brachyury
    byn-PB
    byn-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11927693..11935919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274801.1 → NP_001261730.1  brachyenteron, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEX3
      Conserved Domains (1) summary
      cd00182
      Location:86 → 268
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    2. NM_079307.2 → NP_524031.2  brachyenteron, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524031.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55965, Q9VTQ7
      Conserved Domains (1) summary
      cd00182
      Location:86 → 268
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEX3 M9PEX3
    P55965.2 P55965

    Gene LinkOut

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