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    raskol raskol [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    raskolprovided by FlyBase
    Official Full Name
    raskolprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261570
    Locus tag
    Dmel_CG42684
    See related
    AllianceGenome:FB:FBgn0261570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15816; CG32559; CG32560; CG42270; CG42684; CG5898; CG5960; Dmel\CG42684; FBpp0112350
    Old locus tag
    Dmel_CG15816; Dmel_CG32559; Dmel_CG32560; Dmel_CG42270
    Summary
    Predicted to be involved in negative regulation of Ras protein signal transduction. Located in apical cortex. Is expressed in adult brain cell body rind and organism. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in artery disease (multiple); autosomal dominant intellectual developmental disorder 5; lung cancer; prostate cancer; and stomach cancer. Orthologous to several human genes including DAB2IP (DAB2 interacting protein); RASAL2 (RAS protein activator like 2); and SYNGAP1 (synaptic Ras GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See raskol in Genome Data Viewer
    Location:
    16C1-16C8; 1-58 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17710144..17752007)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17604177..17646040)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene par-6 Neighboring gene uncharacterized protein Neighboring gene unc-4 Neighboring gene Ods-site homeobox

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structured inquiry-based learning: Drosophila GAL4 enhancer trap characterization in an undergraduate laboratory course. Dunne CR, et al. PLoS Biol, 2014 Dec. PMID 25549104, Free PMC Article
    2. Evolution of the Ras-like small GTPases and their regulators. van Dam TJ, et al. Small GTPases, 2011 Jan. PMID 21686276, Free PMC Article
    3. Drosophila olfaction as a model system for studying human neurological disorders. Sarkar S, et al. J Biosci, 2023. PMID 37929819
    4. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
    5. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex HDA PubMed 

    General protein information

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    Preferred Names
    raskol
    Names
    CG42684-PA
    CG42684-PB
    CG42684-PC
    CG42684-PD
    CG42684-PE
    CG42684-PF
    CG42684-PG
    CG42684-PH
    CG42684-PI
    raskol-PA
    raskol-PB
    raskol-PC
    raskol-PD
    raskol-PE
    raskol-PF
    raskol-PG
    raskol-PH
    raskol-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      17710144..17752007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133012.5 → NP_573240.1  raskol, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573240.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8
      Related
      FBpp0291974
      Conserved Domains (5) summary
      cd04013
      Location:268 → 421
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:412 → 739
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:403 → 732
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:162 → 276
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:203 → 267
      PH; PH domain

    2. NM_001201734.3 → NP_001188663.1  raskol, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8, M9MSB6
      Conserved Domains (5) summary
      cd04013
      Location:301 → 454
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:445 → 772
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:436 → 765
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:195 → 309
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:236 → 300
      PH; PH domain

    3. NM_001298457.1 → NP_001285386.1  raskol, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285386.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8, X2JE83
      Conserved Domains (5) summary
      cd04013
      Location:277 → 430
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:421 → 748
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:412 → 741
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:171 → 285
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:212 → 276
      PH; PH domain

    4. NM_001103542.4 → NP_001097012.1  raskol, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV42, Q8T498, Q95TL0, Q9VX23
      UniProtKB/TrEMBL
      D2NUG8
      Conserved Domains (5) summary
      cd04013
      Location:292 → 445
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:436 → 763
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:427 → 756
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:186 → 300
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:227 → 291
      PH; PH domain

    5. NM_001298458.1 → NP_001285387.1  raskol, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8, X2JKZ0
      Conserved Domains (5) summary
      cd04013
      Location:268 → 421
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:412 → 739
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:403 → 732
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:162 → 276
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:203 → 267
      PH; PH domain

    6. NM_001298456.1 → NP_001285385.1  raskol, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285385.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8, X2JCD6
      Conserved Domains (5) summary
      cd04013
      Location:295 → 448
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:439 → 766
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:430 → 759
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:189 → 303
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:230 → 294
      PH; PH domain

    7. NM_167576.3 → NP_728095.2  raskol, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728095.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG8, Q8IQZ6
      Conserved Domains (5) summary
      cd04013
      Location:295 → 448
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:439 → 766
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:430 → 759
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:189 → 303
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:230 → 294
      PH; PH domain

    8. NM_001298459.1 → NP_001285388.1  raskol, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFL7
      Conserved Domains (5) summary
      cd04013
      Location:721 → 874
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:865 → 1192
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:856 → 1185
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:615 → 729
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:656 → 720
      PH; PH domain

    9. NM_001201733.1 → NP_001188662.1  raskol, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSE8
      Conserved Domains (5) summary
      cd04013
      Location:721 → 874
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:865 → 1192
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      smart00323
      Location:856 → 1185
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd13262
      Location:615 → 729
      PH_RasSynGAP-like; Synaptic Ras-GTPase activating protein family Pleckstrin homology (PH) domain
      pfam00169
      Location:656 → 720
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MSB6 M9MSB6
    M9MSE8 M9MSE8
    Q8IQZ6 Q8IQZ6
    Q8T498.3 Q8T498
    X2JCD6 X2JCD6
    X2JE83 X2JE83
    X2JFL7 X2JFL7
    X2JKZ0 X2JKZ0

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