nAChRalpha7 nicotinic Acetylcholine Receptor alpha7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nAChRalpha7provided by FlyBase
Official Full Name: nicotinic Acetylcholine Receptor alpha7provided by FlyBase
Primary source: FLYBASE:FBgn0086778
Locus tag: Dmel_CG32538
See related: AllianceGenome:FB:FBgn0086778
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AcR-Dalpha7; CG32538; CG8082; CG8109; CT24218; Da7; Dalpha7; Dalpha7 nAChR; Dalpha7-nAChR; Dalpha7nAChRs; Dmel\CG32538; gfa; gfA; jpl; nAChR; nAChR-Dalpha7; nAChR-gfa; nAchRa7; nAcRalpha-18C; nAcRalpha-7; nAcRalpha18C; nj507; nj520; nj522; nj54; nj75
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including chemical synaptic transmission; jump response; and visual behavior. Located in dendritic spine and postsynaptic density. Part of acetylcholine-gated channel complex. Is expressed in adult head; adult periesophageal neuropils; antennal mechanosensory and motor center; synaptic neuropil domain; and visual system neurons. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to human CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion) and CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 18C2-18C3; 1-62 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (19327075..19348447, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (19221108..19242480, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of postsynaptic Dalpha7nAChRs caused a significant increase in the length of proximal dendrites, i.e., the cholinergic dendritic domain.
Title: Intra-neuronal Competition for Synaptic Partners Conserves the Amount of Dendritic Building Material.
essential role for the Dalpha7 nicotinic acetylcholine receptor in giant fiber-mediated escape in Drosophila
Title: The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
In addition to the formation of homomeric nAChR complexes, evidence has been obtained from both radioligand binding and co-immunoprecipitation studies for the co-assembly of Dalpha6 and Dalpha7 into heteromeric cell surface complexes
Title: Molecular characterization of Dalpha6 and Dalpha7 nicotinic acetylcholine receptor subunits from Drosophila: formation of a high-affinity alpha-bungarotoxin binding site revealed by expression of subunit chimeras.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c19330843-19330629 mobile_element_type = transposon:INE-1{}5595

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in jump response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IEP Inferred from Expression Pattern more info	PubMed
involved_in visual behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IPI Inferred from Physical Interaction more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinic acetylcholine receptor alpha7

Names: CG32538-PA; CG32538-PD; CG32538-PE; CG32538-PF; Dalpha7; Dalpha7 subunit of the acetylcholine receptor; Dalpha7 subunit of the nicotinic acetylcholine receptor; giant fiber A; giant fibre A; jumpless; nAChRalpha7-PA; nAChRalpha7-PD; nAChRalpha7-PE; nAChRalpha7-PF; nicotinic acetylcholine receptor alpha 18C; non-jumper-507; non-jumper-520; non-jumper-522; non-jumper-54; non-jumper-75; shaker cognate L

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

19327075..19348447 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167645.4 → NP_728239.3 nicotinic acetylcholine receptor alpha7, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728239.3

Status: REVIEWED

UniProtKB/TrEMBL

A4GXC7, Q7KUV2, Q9VWI9

Conserved Domains (3) summary

TIGR00860
Location:59 → 548

LIC; Cation transporter family protein

pfam02931
Location:61 → 268

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:275 → 552

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001298507.1 → NP_001285436.1 nicotinic acetylcholine receptor alpha7, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285436.1

Status: REVIEWED

UniProtKB/TrEMBL

A4GXC7, Q7KUV2, Q9VWI9

Conserved Domains (3) summary

TIGR00860
Location:59 → 548

LIC; Cation transporter family protein

pfam02931
Location:61 → 268

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:275 → 552

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_206791.3 → NP_996514.1 nicotinic acetylcholine receptor alpha7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996514.1

Status: REVIEWED

UniProtKB/TrEMBL

A4GXC7, Q7KUV2, Q9VWI9

Conserved Domains (3) summary

TIGR00860
Location:59 → 548

LIC; Cation transporter family protein

pfam02931
Location:61 → 268

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:275 → 552

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001169324.2 → NP_001162795.1 nicotinic acetylcholine receptor alpha7, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162795.1

Status: REVIEWED

UniProtKB/TrEMBL

A4GXC7, E1JJR2

Conserved Domains (3) summary

TIGR00860
Location:59 → 548

LIC; Cation transporter family protein

pfam02931
Location:61 → 268

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:275 → 552

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region