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    DCTN6-p27 Dynactin 6, p27 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DCTN6-p27provided by FlyBase
    Official Full Name
    Dynactin 6, p27 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086446
    Locus tag
    Dmel_CG17347
    See related
    AllianceGenome:FB:FBgn0086446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Ce; CG17347; DCTN6; Dmel\CG17347; l(2)37Ce; l(2)37Ce)E62; l(2)E62; P27
    Summary
    Predicted to enable dynein complex binding activity. Predicted to be involved in mitotic spindle organization. Predicted to be part of dynactin complex. Orthologous to human DCTN6 (dynactin subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See DCTN6-p27 in Genome Data Viewer
    Location:
    37C1-37C1; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19132323..19133097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19132323..19133097)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 37Cd Neighboring gene Asparaginyl-tRNA synthetase Neighboring gene RNA polymerase I and III subunit D Neighboring gene brain tumor Neighboring gene long non-coding RNA:CR44977 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh JL, et al. Mol Gen Genet, 1985. PMID 2989656
    2. Evolution of the eukaryotic dynactin complex, the activator of cytoplasmic dynein. Hammesfahr B, et al. BMC Evol Biol, 2012 Jun 22. PMID 22726940, Free PMC Article
    3. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
    4. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article
    5. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynactin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynactin 6, p27 subunit
    Names
    CG17347-PA
    DCTN6-p27-PA
    Dynactin6 p27
    P27 DYNACTIN
    dynactin, p27 subunit
    lethal (2) 37Ce

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      19132323..19133097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136105.3 → NP_609949.1  dynactin 6, p27 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIZ1
      Related
      FBpp0080701
      Conserved Domains (1) summary
      cd04646
      Location:8 → 173
      LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIZ1 Q9VIZ1

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