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    CG11825 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11825provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033519
    Locus tag
    Dmel_CG11825
    See related
    AllianceGenome:FB:FBgn0033519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE25483; CG13432; dHIG1; Dmel\CG11825
    Summary
    Involved in copper ion homeostasis. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in embryonic/larval hindgut; embryonic/larval midgut; and organism. Orthologous to several human genes including HIGD1B (HIG1 hypoxia inducible domain family member 1B) and HIGD1C (HIG1 hypoxia inducible domain family member 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11825 in Genome Data Viewer
    Location:
    47A7-47A7; 2-62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10420414..10423650, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6307919..6311155, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene slowpoke 2 Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxiredoxin 6b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of three parent genes and their retrogene copies in Drosophila species. O'Neill RS, et al. Int J Evol Biol, 2013. PMID 23841016, Free PMC Article
    2. The archipelago ubiquitin ligase subunit acts in target tissue to restrict tracheal terminal cell branching and hypoxic-induced gene expression. Mortimer NT, et al. PLoS Genet, 2013. PMID 23459416, Free PMC Article
    3. The genetic basis of adaptation to copper pollution in Drosophila melanogaster. Everman ER, et al. Front Genet, 2023. PMID 37082199, Free PMC Article
    4. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Chen S, et al. Cell Rep, 2012 Feb 23. PMID 22832161, Free PMC Article
    5. Characterizing the genetic basis of copper toxicity in Drosophila reveals a complex pattern of allelic, regulatory, and behavioral variation. Everman ER, et al. Genetics, 2021 Mar 3. PMID 33683361, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in copper ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11825-PA
    CG11825-PC
    CG11825-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10420414..10423650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273936.2 → NP_001260865.1  uncharacterized protein Dmel_CG11825, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260865.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEI1
      Conserved Domains (1) summary
      pfam04588
      Location:63 → 111
      HIG_1_N; Hypoxia induced protein conserved region

    2. NM_001273937.1 → NP_001260866.1  uncharacterized protein Dmel_CG11825, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ6
      Conserved Domains (1) summary
      pfam04588
      Location:1 → 47
      HIG_1_N; Hypoxia induced protein conserved region

    3. NM_136739.3 → NP_610583.1  uncharacterized protein Dmel_CG11825, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JW46
      Related
      FBpp0087407
      Conserved Domains (1) summary
      pfam04588
      Location:27 → 75
      HIG_1_N; Hypoxia induced protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEI1 A0A0B4KEI1
    A0A0B4KEQ6 A0A0B4KEQ6
    Q7JW46 Q7JW46

    Gene LinkOut

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