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    tej tejas [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tejprovided by FlyBase
    Official Full Name
    tejasprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033921
    Locus tag
    Dmel_CG8589
    See related
    AllianceGenome:FB:FBgn0033921
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1D11; CG8589; Dmel\CG8589; TDRD5; Tej; Tejas
    Summary
    Involved in piRNA-mediated retrotransposon silencing by mRNA destabilization and secondary piRNA processing. Located in P granule. Orthologous to human TDRD5 (tudor domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tej in Genome Data Viewer
    Location:
    50F1-50F1; 2-70 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14300103..14302353, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10187608..10189858, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene convoluted Neighboring gene I[[h]] channel Neighboring gene Shroom Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage. Jeske M, et al. Genes Dev, 2017 May 1. PMID 28536148, Free PMC Article
    2. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis. Lin Y, et al. J Cell Biol, 2023 Oct 2. PMID 37555815, Free PMC Article
    3. Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethal. Primus S, et al. PLoS Genet, 2019 Jul. PMID 31329582, Free PMC Article
    4. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Webster A, et al. Mol Cell, 2015 Aug 20. PMID 26295961, Free PMC Article
    5. Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas. Patil VS, et al. Curr Biol, 2010 Apr 27. PMID 20362446

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis.
      Title: Tejas functions as a core component in nuage assembly and precursor processing in Drosophila piRNA biogenesis.
    2. Data suggest that Tejas contributes to the formation of a macromolecular complex at perinuclear region and engages it in the production of germline piRNAs.
      Title: Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secondary piRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing by mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tejas
    Names
    CG8589-PA
    anon-fast-evolving-1D11
    tej-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14300103..14302353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137106.3 → NP_610950.2  tejas [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610950.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9P1
      Related
      FBpp0086689
      Conserved Domains (2) summary
      cd09972
      Location:7 → 93
      LOTUS_TDRD_OSKAR; The first LOTUS domain in Oskar and Tudor-containing proteins 5 and 7
      pfam00567
      Location:379 → 488
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9P1 A1Z9P1
    Q8SZ14 Q8SZ14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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