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    CG5493 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5493provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034364
    Locus tag
    Dmel_CG5493
    See related
    AllianceGenome:FB:FBgn0034364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5493
    Summary
    Predicted to enable cysteine dioxygenase activity and ferrous iron binding activity. Predicted to be involved in L-cysteine catabolic process. Is expressed in embryonic ventral epidermis; embryonic/larval salivary gland; embryonic/larval salivary gland body; larval foregut atrium; and salivary gland body primordium. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5493 in Genome Data Viewer
    Location:
    55E2-55E2; 2-86 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18616692..18619328, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14504197..14506833, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 7 Neighboring gene uncharacterized protein Neighboring gene Secretory 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A toolkit for high-throughput, cross-species gene engineering in Drosophila. Ejsmont RK, et al. Nat Methods, 2009 Jun. PMID 19465918
    2. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    3. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Parkhitko AA, et al. Genes Dev, 2016 Jun 15. PMID 27313316, Free PMC Article
    4. Genes and pathways affected by CAG-repeat RNA-based toxicity in Drosophila. Shieh SY, et al. Hum Mol Genet, 2011 Dec 15. PMID 21933837, Free PMC Article
    5. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-cysteine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5493-PA
    CG5493-PB
    CG5493-PC
    CG5493-PD
    NP_001246409.1
    NP_001246410.1
    NP_001246411.1
    NP_611348.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18616692..18619328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259480.2 → NP_001246409.1  uncharacterized protein Dmel_CG5493, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBA8, A8E780
      Conserved Domains (1) summary
      cl21464
      Location:29 → 212
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_001259482.2 → NP_001246411.1  uncharacterized protein Dmel_CG5493, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246411.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBA8, A8E780
      Conserved Domains (1) summary
      cl21464
      Location:29 → 212
      cupin_like; Conserved domain found in cupin and related proteins

    3. NM_001259481.2 → NP_001246410.1  uncharacterized protein Dmel_CG5493, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246410.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBA8, A8E780
      Conserved Domains (1) summary
      cl21464
      Location:29 → 212
      cupin_like; Conserved domain found in cupin and related proteins

    4. NM_137504.3 → NP_611348.1  uncharacterized protein Dmel_CG5493, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBA8, A8E780
      Related
      FBpp0085892
      Conserved Domains (1) summary
      cl21464
      Location:29 → 212
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZBA8 A1ZBA8

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