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    Elo68alpha Elongase 68alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317841, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elo68alphaprovided by FlyBase
    Official Full Name
    Elongase 68alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052072
    Locus tag
    Dmel_CG32072
    See related
    AllianceGenome:FB:FBgn0052072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32072; CG6261; Dmel\CG32072; elo68alpha
    Summary
    Enables fatty acid elongase activity. Involved in fatty acid elongation, unsaturated fatty acid; long-chain fatty acid biosynthetic process; and pheromone biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in corneal dystrophy and spinocerebellar ataxia type 34. Orthologous to human ELOVL4 (ELOVL fatty acid elongase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Elo68alpha in Genome Data Viewer
    Location:
    68A6-68A6; 3-34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11101875..11103030, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11094975..11096130, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beta-Amyloid precursor protein binding protein 1 Neighboring gene Elongase 68beta Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster. Chertemps T, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360514, Free PMC Article
    2. A new elongase selectively expressed in Drosophila male reproductive system. Chertemps T, et al. Biochem Biophys Res Commun, 2005 Aug 12. PMID 15975553
    3. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Szafer-Glusman E, et al. Curr Biol, 2008 Sep 23. PMID 18804373, Free PMC Article
    4. The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. Jung A, et al. J Cell Sci, 2007 Aug 15. PMID 17666430
    5. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Grönke S, et al. Cell Metab, 2005 May. PMID 16054079

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid elongase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, unsaturated fatty acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pheromone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongase 68alpha
    Names
    CG32072-PA
    Elo68alpha-PA
    NP_729666.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11101875..11103030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168440.3 → NP_729666.2  elongase 68alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729666.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5JZZ4, Q8IQF0
      Conserved Domains (1) summary
      pfam01151
      Location:23 → 260
      ELO; GNS1/SUR4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JZZ4 Q5JZZ4

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