U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tey teyrha-meyrha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40146, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    teyprovided by FlyBase
    Official Full Name
    teyrha-meyrhaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036899
    Locus tag
    Dmel_CG8780
    See related
    AllianceGenome:FB:FBgn0036899
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8780; Dmel\CG8780; Tey
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of DNA-templated transcription and synaptic target recognition. Located in nucleus. Is expressed in several structures, including dorsal thoracic disc; ganglia; larval digestive system; muscle cell; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tey in Genome Data Viewer
    Location:
    76B11-76C1; 3-46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19650506..19664104, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19643606..19657204, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ring finger protein 146 Neighboring gene Ornithine aminotransferase precursor Neighboring gene long non-coding RNA:CR44678 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila. Frasch M, et al. Development, 2023 Sep 15. PMID 37642089, Free PMC Article
    2. A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. Swan LE, et al. Genes Dev, 2004 Jan 15. PMID 14729572, Free PMC Article
    3. Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity. Inaki M, et al. Development, 2010 Jul. PMID 20504957, Free PMC Article
    4. Role of FGFR signaling in the morphogenesis of the Drosophila visceral musculature. Mandal L, et al. Dev Dyn, 2004 Oct. PMID 15366011
    5. Target-dependent retrograde signaling mediates synaptic plasticity at the Drosophila neuromuscular junction. Berke B, et al. Dev Neurobiol, 2019 Nov. PMID 31950660, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.
      Title: The RNF220 domain nuclear factor Teyrha-Meyrha (Tey) regulates the migration and differentiation of specific visceral and somatic muscles in Drosophila.
    2. Results suggest that Tey determines target specificity by repressing the expression of Toll; these results reveal a mechanism for generating synaptic specificity that relies on the negative regulation of a repulsive target cue.
      Title: Drosophila Tey represses transcription of the repulsive cue Toll and generates neuromuscular target specificity.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    teyrha-meyrha
    Names
    CG8780-PA
    CG8780-PB
    CG8780-PC
    CG8780-PD
    tey-PA
    tey-PB
    tey-PC
    tey-PD
    teyrha meyrha
    teyrha-meyhra

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19650506..19664104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275130.2 → NP_001262059.1  teyrha-meyrha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCZ6
      Conserved Domains (1) summary
      pfam15926
      Location:318 → 449
      RNF220; E3 ubiquitin-protein ligase RNF220

    2. NM_001144509.3 → NP_001137981.1  teyrha-meyrha, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z079
      Conserved Domains (1) summary
      pfam15926
      Location:328 → 459
      RNF220; E3 ubiquitin-protein ligase RNF220

    3. NM_001275131.1 → NP_001262060.1  teyrha-meyrha, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFP2
      Conserved Domains (1) summary
      pfam15926
      Location:270 → 401
      RNF220; E3 ubiquitin-protein ligase RNF220

    4. NM_140883.2 → NP_649140.1  teyrha-meyrha, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649140.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VW27
      Related
      FBpp0074728
      Conserved Domains (1) summary
      pfam15926
      Location:328 → 459
      RNF220; E3 ubiquitin-protein ligase RNF220
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z079 B7Z079
    M9PCZ6 M9PCZ6
    M9PFP2 M9PFP2
    Q8SY01 Q8SY01
    Q9VW27.2 Q9VW27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools