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    plh pasang lhamu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plhprovided by FlyBase
    Official Full Name
    pasang lhamuprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037292
    Locus tag
    Dmel_CG2022
    See related
    AllianceGenome:FB:FBgn0037292
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2022; Dmel\CG2022; Mpv17-like protein
    Summary
    Predicted to enable monoatomic ion channel activity. Involved in response to hypoxia. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See plh in Genome Data Viewer
    Location:
    82E4-82E5; 3-47.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4986500..5011031, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (812222..836753, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43478 Neighboring gene long non-coding RNA:CR43424 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45585 Neighboring gene long non-coding RNA:CR46352

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila. Mossman JA, et al. Mol Biol Evol, 2017 Feb 1. PMID 28110272, Free PMC Article
    2. A Drosophila model of the neurological symptoms in Mpv17-related diseases. Kodani A, et al. Sci Rep, 2022 Dec 31. PMID 36587049, Free PMC Article
    3. Drosophila Mpv17 forms an ion channel and regulates energy metabolism. Corrà S, et al. iScience, 2023 Oct 20. PMID 37810222, Free PMC Article
    4. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
    5. piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila. Hacker U, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12802016, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c5009136-5002385 mobile_element_type = transposon:17.6{}1213

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pasang lhamu
    Names
    CG2022-PB
    plh-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4986500..5011031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141254.2 → NP_649511.2  pasang lhamu [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649511.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJP1, Q4V6H9, Q9VN75
      Conserved Domains (1) summary
      pfam04117
      Location:108 → 171
      Mpv17_PMP22; Mpv17 / PMP22 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VN75 Q9VN75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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