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    Pnn Pinin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41185, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pnnprovided by FlyBase
    Official Full Name
    Pininprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037737
    Locus tag
    Dmel_CG8383
    See related
    AllianceGenome:FB:FBgn0037737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8383; Dmel\CG8383; dPnn; FBgn0037737
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in dorsal pharyngeal muscle primordium; head visceral muscle primordium; organism; somatic muscle primordium; and visceral muscle primordium. Orthologous to human PNN (pinin, desmosome associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pnn in Genome Data Viewer
    Location:
    85E6-85E6; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9740899..9742844)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5566621..5568566)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 85E Neighboring gene sidestep VII Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. Costa E, et al. Chromosome Res, 2006. PMID 16823614
    2. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Murachelli AG, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388736
    3. The exon junction complex: a splicing factor for long intron containing transcripts? Ashton-Beaucage D, et al. Fly (Austin), 2011 Jul-Sep. PMID 21478676
    4. The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila. Wang M, et al. Genetics, 2018 Mar. PMID 29263027, Free PMC Article
    5. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Barbosa I, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961380

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    pinin
    Names
    CG8383-PA
    CG8383-PB
    Pnn-PA
    Pnn-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9740899..9742844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104257.2 → NP_001097727.1  pinin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQW3, Q8IFW3
      Conserved Domains (1) summary
      pfam04696
      Location:126 → 250
      Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region

    2. NM_141677.3 → NP_649934.1  pinin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649934.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IFW3, Q9VH84
      Related
      FBpp0081604
      Conserved Domains (1) summary
      pfam04696
      Location:126 → 250
      Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JQW3 A8JQW3
    Q8IFW3 Q8IFW3
    Q9VH84 Q9VH84

    Gene LinkOut

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