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    CG42342 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354466, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG42342provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259244
    Locus tag
    Dmel_CG42342
    See related
    AllianceGenome:FB:FBgn0259244
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11769; CG14888; CG14889; CG14890; CG42243; Dmel\CG42342
    Old locus tag
    Dmel_CG11769; Dmel_CG14888; Dmel_CG14889; Dmel_CG14890
    Summary
    Predicted to be an extracellular matrix structural constituent conferring tensile strength. Predicted to be involved in extracellular matrix organization. Predicted to be part of collagen type IX trimer. Predicted to be active in basement membrane and extracellular space. Is expressed in several structures, including adult brain cell body rind; anlage in statu nascendi; epidermis; ganglia; and head epidermis primordium. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 19. Orthologous to human COL13A1 (collagen type XIII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42342 in Genome Data Viewer
    Location:
    89B18-89B20; 3-58 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16502770..16571363)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12328492..12397085)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 89a Neighboring gene Death executioner caspase related to Apopain/Yama Neighboring gene long non-coding RNA:CR46030 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein retention in the endoplasmic reticulum rescues Aβ toxicity in Drosophila. Catterson JH, et al. Neurobiol Aging, 2023 Dec. PMID 37837732, Free PMC Article
    2. Target genes of Dpp/BMP signaling pathway revealed by transcriptome profiling in the early D.melanogaster embryo. Dominguez C, et al. Gene, 2016 Oct 10. PMID 27397649
    3. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    4. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. Kaushik G, et al. J Cell Mol Med, 2012 Aug. PMID 22225769, Free PMC Article
    5. The female-specific doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. Chatterjee SS, et al. Development, 2011 Mar. PMID 21343364

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent conferring tensile strength IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of collagen type IX trimer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42342-PD
    CG42342-PH
    CG42342-PK
    CG42342-PL
    CG42342-PM
    CG42342-PN
    CG42342-PO
    CG42342-PP
    CG42342-PQ
    CG42342-PR
    CG42342-PS
    CG42342-PT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16502770..16571363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202305.2 → NP_001189234.1  uncharacterized protein Dmel_CG42342, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189234.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDF5
      Conserved Domains (2) summary
      pfam01391
      Location:660 → 718
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    2. NM_001144589.3 → NP_001138061.1  uncharacterized protein Dmel_CG42342, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138061.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0K6, B7Z0K7, B7Z0K8, B7Z0K9, Q86NZ7
      Conserved Domains (2) summary
      pfam01391
      Location:660 → 717
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    3. NM_001275712.1 → NP_001262641.1  uncharacterized protein Dmel_CG42342, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGA1
      Conserved Domains (2) summary
      pfam01391
      Location:642 → 700
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    4. NM_001260214.2 → NP_001247143.1  uncharacterized protein Dmel_CG42342, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7C8
      Conserved Domains (2) summary
      pfam01391
      Location:642 → 699
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    5. NM_001202306.2 → NP_001189235.2  uncharacterized protein Dmel_CG42342, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189235.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JDA4
      Conserved Domains (2) summary
      pfam01391
      Location:642 → 699
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    6. NM_001170160.2 → NP_001163631.2  uncharacterized protein Dmel_CG42342, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163631.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIM8
      Conserved Domains (2) summary
      pfam01391
      Location:460 → 518
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    7. NM_001260212.2 → NP_001247141.2  uncharacterized protein Dmel_CG42342, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247141.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K668
      Conserved Domains (2) summary
      pfam01391
      Location:637 → 695
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    8. NM_001260213.2 → NP_001247142.1  uncharacterized protein Dmel_CG42342, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247142.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6A0
      Conserved Domains (2) summary
      pfam01391
      Location:637 → 694
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    9. NM_001144592.3 → NP_001138064.2  uncharacterized protein Dmel_CG42342, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138064.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0K8
      Conserved Domains (2) summary
      pfam01391
      Location:637 → 694
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    10. NM_001275711.1 → NP_001262640.1  uncharacterized protein Dmel_CG42342, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH90
      Conserved Domains (2) summary
      pfam01391
      Location:455 → 513
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    11. NM_001144591.3 → NP_001138063.2  uncharacterized protein Dmel_CG42342, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138063.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0K8
      Conserved Domains (2) summary
      pfam01391
      Location:348 → 395
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)

    12. NM_001144590.3 → NP_001138062.2  uncharacterized protein Dmel_CG42342, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138062.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B7Z0K8
      Conserved Domains (2) summary
      pfam01391
      Location:343 → 390
      Collagen; Collagen triple helix repeat (20 copies)
      pfam15960
      Location:130 → 210
      DUF4763; Domain of unknown function (DUF4763)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JDA4 A0A0B4JDA4
    A0A0B4JDF5 A0A0B4JDF5
    A0A0B4K668 A0A0B4K668
    A0A0B4K6A0 A0A0B4K6A0
    A0A0B4K7C8 A0A0B4K7C8
    A0A0B4KGA1 A0A0B4KGA1
    A0A0B4KH90 A0A0B4KH90
    B7Z0K8.1 B7Z0K8
    E1JIM8 E1JIM8

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