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    P5cr-2 Pyrroline-5-carboxylate reductase-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P5cr-2provided by FlyBase
    Official Full Name
    Pyrroline-5-carboxylate reductase-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038516
    Locus tag
    Dmel_CG5840
    See related
    AllianceGenome:FB:FBgn0038516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5840; CT18319; Dmel\CG5840
    Summary
    Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Is expressed in several structures, including adult head; adult heart; amnioserosa; embryonic/larval midgut; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to several human genes including PYCR1 (pyrroline-5-carboxylate reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See P5cr-2 in Genome Data Viewer
    Location:
    90B3-90B3; 3-61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17534815..17537136)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13360537..13362858)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44349 Neighboring gene uncharacterized protein Neighboring gene lethal (3) 07882 Neighboring gene Splicing factor 1 Neighboring gene Peroxiredoxin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4. Baltzer C, et al. PLoS One, 2009 Sep 9. PMID 19742324, Free PMC Article
    2. Mating alters gene expression patterns in Drosophila melanogaster male heads. Ellis LL, et al. BMC Genomics, 2010 Oct 11. PMID 20937114, Free PMC Article
    3. Drosophila as a diet discovery tool for treating amino acid disorders. Mele S, et al. Trends Endocrinol Metab, 2023 Feb. PMID 36567227
    4. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    5. Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9. Schwartz S, et al. Genetics, 2016 Jul. PMID 27182943, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Pyrroline-5-carboxylate reductase-like 2
    Names
    CG5840-PA
    CG5840-PB
    CG5840-PC
    CG5840-PD
    P5cr-2-PA
    P5cr-2-PB
    P5cr-2-PC
    P5cr-2-PD
    Pyrroline-5-carboxylate reductase
    NP_001262670.1
    NP_001262671.1
    NP_650632.1
    NP_732243.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17534815..17537136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275741.1 → NP_001262670.1  Pyrroline-5-carboxylate reductase-like 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262670.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGC5
      Conserved Domains (3) summary
      PLN02688
      Location:2 → 249
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:28 → 80
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:142 → 246
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    2. NM_001275742.1 → NP_001262671.1  Pyrroline-5-carboxylate reductase-like 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGC5
      Conserved Domains (3) summary
      PLN02688
      Location:2 → 249
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:28 → 80
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:142 → 246
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    3. NM_142375.3 → NP_650632.1  Pyrroline-5-carboxylate reductase-like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEJ3
      Related
      FBpp0082895
      Conserved Domains (3) summary
      PLN02688
      Location:6 → 270
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:8 → 101
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:163 → 267
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

    4. NM_169762.1 → NP_732243.1  Pyrroline-5-carboxylate reductase-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732243.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN96
      Related
      FBpp0082896, FBtr0083455
      Conserved Domains (2) summary
      PRK11880
      Location:2 → 172
      PRK11880; pyrroline-5-carboxylate reductase; Reviewed
      pfam14748
      Location:64 → 168
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGC5 A0A0B4KGC5
    Q8IN96 Q8IN96
    Q9VEJ3 Q9VEJ3

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