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    Rab2 Rab2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35577, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab2provided by FlyBase
    Official Full Name
    Rab2provided by FlyBase
    Primary source
    FLYBASE:FBgn0014009
    Locus tag
    Dmel_CG3269
    See related
    AllianceGenome:FB:FBgn0014009
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3269; Dmel\CG3269; DmRab2; Drab2; DRab2; DRAB2; O18333; rab2
    Summary
    Enables GTP binding activity and magnesium ion binding activity. Involved in several processes, including T-tubule organization; regulation of glutamate receptor clustering; and vesicle organization. Located in several cellular components, including endoplasmic reticulum exit site; type II terminal bouton; and vacuolar membrane. Is expressed in several structures, including brain; imaginal disc; mesoderm; mushroom body; and synaptic neuropil domain. Orthologous to several human genes including RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Rab2 in Genome Data Viewer
    Location:
    42C5-42C5; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6696739..6699469)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2584244..2586974)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ribonuclease P/MRP subunit p25 Neighboring gene Tyrosine decarboxylase 2 Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene uncharacterized protein Neighboring gene chaski Neighboring gene long non-coding RNA:CR43611 Neighboring gene mir-4975 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo. Vicidomini R, et al. Nat Commun, 2024 Jul 18. PMID 39025931, Free PMC Article
    2. Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Lardong JA, et al. Acta Crystallogr F Struct Biol Commun, 2015 Jan 1. PMID 25615965, Free PMC Article
    3. Potent New Targets for Autophagy Enhancement to Delay Neuronal Ageing. Szinyákovics J, et al. Cells, 2023 Jun 30. PMID 37443788, Free PMC Article
    4. Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila. Mallik B, et al. Development, 2017 Jun 1. PMID 28455372
    5. Rab2 promotes autophagic and endocytic lysosomal degradation. Lőrincz P, et al. J Cell Biol, 2017 Jul 3. PMID 28483915, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab2 drives axonal transport of dense core vesicles and lysosomal organelles.
      Title: Rab2 drives axonal transport of dense core vesicles and lysosomal organelles.
    2. Drosophila Rab2 is recruited to late endosomal membranes, where it controls the fusion of LAMP-containing biosynthetic carriers and lysosomes to late endosomes.
      Title: Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes.
    3. Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.
      Title: Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.
    4. ICA69 regulates NMJ organization through a pathway that involves PICK1 and Rab2.
      Title: Regulation of neuromuscular junction organization by Rab2 and its effector ICA69 in Drosophila.
    5. Identify Rab2 as a key factor for autophagic and endocytic cargo delivery to and degradation in lysosomes.
      Title: Rab2 promotes autophagic and endocytic lysosomal degradation.
    6. High-resolution crystal structures of Drosophila Rab2 and Rab3 in complex with GMPPNP and magnesium.
      Title: Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in T-tubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye pigment granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of glutamate receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autolysosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in postsynapse of neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in type II terminal bouton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Rab2
    Names
    CG3269-PA
    CG3269-PB
    Rab-protein 2
    Rab2-PA
    Rab2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6696739..6699469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057742.4 → NP_477090.1  Rab2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477090.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18333, Q9U5D5
      Related
      FBpp0085458
      Conserved Domains (1) summary
      PLN03108
      Location:1 → 213
      PLN03108; Rab family protein; Provisional

    2. NM_001273803.1 → NP_001260732.1  Rab2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18333, Q9U5D5
      Conserved Domains (1) summary
      PLN03108
      Location:1 → 213
      PLN03108; Rab family protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18333 O18333
    O18333.1
    Q9U5D5 Q9U5D5

    Gene LinkOut

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