tn thin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tnprovided by FlyBase
Official Full Name: thinprovided by FlyBase
Primary source: FLYBASE:FBgn0265356
Locus tag: Dmel_CG15105
See related: AllianceGenome:FB:FBgn0265356
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: abba; Abba; CG15105; Dmel\CG15105; l(2)tn; Thin; Tn; TRIM32
Summary: Predicted to enable translation repressor activity; ubiquitin protein ligase activity; and zinc ion binding activity. Involved in several processes, including muscle cell cellular homeostasis; myofibril assembly; and positive regulation of glycolytic process. Located in Z disc. Is expressed in embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and somatic muscle cell. Used to study autosomal recessive limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2R. Orthologous to human TRIM2 (tripartite motif containing 2) and TRIM3 (tripartite motif containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 56A2-56A3; 2-87 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18987344..19008944)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14874849..14896449)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.
Title: Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.
Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.
Title: Drosophila TRIM32 cooperates with glycolytic enzymes to promote cell growth.
observations that Abba/Thin modulates these phenotypes suggest that manipulation of Abba/Thin activity levels may be beneficial in Laing distal myopathy.
Title: Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of amino acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in striated muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thin

Names: CG15105-PA; CG15105-PB; CG15105-PC; CG15105-PD; CG15105-PE; CG15105-PF; another B-box affiliate; l(2)thin; tn-PA; tn-PB; tn-PC; tn-PD; tn-PE; tn-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18987344..19008944

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299667.1 → NP_001286596.1 thin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286596.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFP7

Conserved Domains (6) summary

COG3391
Location:984 → 1248

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14954
Location:965 → 1248

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

sd00039
Location:992 → 1035

7WD40; WD40 repeat [structural motif]

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001144235.2 → NP_001137707.1 thin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137707.1

Status: REVIEWED

UniProtKB/TrEMBL

B7YZK8

Conserved Domains (6) summary

COG3391
Location:1253 → 1517

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14954
Location:1234 → 1517

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

sd00039
Location:1261 → 1304

7WD40; WD40 repeat [structural motif]

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_166318.2 → NP_725843.1 thin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725843.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JUV6

Related

FBpp0085756

Conserved Domains (6) summary

COG3391
Location:1089 → 1353

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14954
Location:1070 → 1353

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

sd00039
Location:1097 → 1140

7WD40; WD40 repeat [structural motif]

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001299669.1 → NP_001286598.1 thin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286598.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LG15

Conserved Domains (3) summary

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_001299668.1 → NP_001286597.1 thin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286597.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFW8

Conserved Domains (6) summary

COG3391
Location:1013 → 1277

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14954
Location:994 → 1277

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

sd00039
Location:1021 → 1064

7WD40; WD40 repeat [structural motif]

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
NM_137546.3 → NP_611390.2 thin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611390.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7JUV6

Related

FBpp0085757

Conserved Domains (6) summary

COG3391
Location:1089 → 1353

YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]

cd00162
Location:9 → 54

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd14954
Location:1070 → 1353

NHL_TRIM71_like; NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins

pfam00643
Location:94 → 122

zf-B_box; B-box zinc finger

sd00039
Location:1097 → 1140

7WD40; WD40 repeat [structural motif]

cl23765
Location:131 → 231

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits