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    Kyat Kynurenine aminotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41433, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kyatprovided by FlyBase
    Official Full Name
    Kynurenine aminotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037955
    Locus tag
    Dmel_CG6950
    See related
    AllianceGenome:FB:FBgn0037955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6950; Dmel\CG6950; kyat
    Summary
    Predicted to enable cysteine-S-conjugate beta-lyase activity and kynurenine-oxoglutarate transaminase activity. Predicted to be involved in biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval fat body; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including KYAT3 (kynurenine aminotransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kyat in Genome Data Viewer
    Location:
    86F9-86F9; 3-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11820381..11822493, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7646103..7648215, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Chloride channel-a Neighboring gene glorund Neighboring gene Cytochrome c oxidase subunit 5A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene shadow

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kynurenine Metabolism in the Fat Body Non-autonomously Regulates Imaginal Disc Repair in Drosophila. Kashio S, et al. iScience, 2020 Dec 18. PMID 33376969, Free PMC Article
    2. Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Brinzer RA, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26474926
    3. Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism. Navrotskaya V, et al. Neurotox Res, 2018 Aug. PMID 29619629
    4. Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging. Oxenkrug G, et al. Exp Biol Med (Maywood), 2023 Apr. PMID 37300401, Free PMC Article
    5. Tryptophan regulates Drosophila zinc stores. Garay E, et al. Proc Natl Acad Sci U S A, 2022 Apr 19. PMID 35412912, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kynurenine-oxoglutarate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kynurenic acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine aminotransferase
    Names
    CG6950-PA
    CG6950-PB
    CG6950-PC
    CG6950-PD
    Kyat-PA
    Kyat-PB
    Kyat-PC
    Kyat-PD
    NP_650121.1
    NP_731643.2
    NP_731644.2
    NP_788640.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11820381..11822493 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169438.2 → NP_731644.2  kynurenine aminotransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731644.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ5, Q8SXC2, Q9VGH3
      Related
      FBpp0081993
      Conserved Domains (2) summary
      cd00609
      Location:64 → 448
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:56 → 449
      PRK08912; hypothetical protein; Provisional

    2. NM_169437.2 → NP_731643.2  kynurenine aminotransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ5, Q8SXC2, Q9VGH3
      Related
      FBpp0081994, FBtr0082520
      Conserved Domains (2) summary
      cd00609
      Location:64 → 448
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:56 → 449
      PRK08912; hypothetical protein; Provisional

    3. NM_176463.2 → NP_788640.1  kynurenine aminotransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ5, Q8SXC2, Q9VGH3
      Related
      FBpp0081996
      Conserved Domains (2) summary
      cd00609
      Location:64 → 448
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:56 → 449
      PRK08912; hypothetical protein; Provisional

    4. NM_141864.2 → NP_650121.1  kynurenine aminotransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INJ5, Q8SXC2, Q9VGH3
      Related
      FBpp0081995
      Conserved Domains (2) summary
      cd00609
      Location:64 → 448
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PRK08912
      Location:56 → 449
      PRK08912; hypothetical protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGP9 Q8IGP9
    Q8SXC2 Q8SXC2

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