rump rumpelstiltskin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rumpprovided by FlyBase
Official Full Name: rumpelstiltskinprovided by FlyBase
Primary source: FLYBASE:FBgn0267790
Locus tag: Dmel_CG9373
See related: AllianceGenome:FB:FBgn0267790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg9373; CG9373; Dmel\CG9373; hnRNP M; HnRNP-S5; hrp59; Hrp59; p70; p75; Rump; S5
Summary: Enables mRNA 3'-UTR binding activity. Involved in pole cell development and pole plasm oskar mRNA localization. Located in chromatin; cytoplasm; and omega speckle. Part of ribonucleoprotein complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including MYEF2 (myelin expression factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 85D18-85D19; 3-48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9505853..9510324, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5331575..5336046, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suggesting that Rump and Lost are part of a core localization complex that promotes utilization of the late localization pathway by multiple mRNAs in parallel
Title: A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin.
Data show that depletion of Hrp59 by RNA interference reduces the levels of Rrp4 at transcription sites, which suggests that Hrp59 is needed for the exosome to stably interact with nascent pre-mRNPs.
Title: The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins.
Rumpelstiltskin (rump) regulates anterior-posterior axis patterning by functioning as a direct-acting nanos mRNA localization factor.
Title: The Drosophila hnRNP M homolog Rumpelstiltskin regulates nanos mRNA localization.
the ability of HRP59 to regulate the alternative splicing of its own pre-mRNA serves in a negative feedback loop that controls the levels of the HRP59 protein and maintains the homeostasis of the splicing environment.
Title: The Drosophila heterogeneous nuclear ribonucleoprotein M protein, HRP59, regulates alternative splicing and controls the production of its own mRNA.
Hrp59 is required for the expression of target mRNAs. Hrp59 binds preferentially to exonic splicing enhancers and our results provide new insights into the role of hnRNP M in splicing regulation.
Title: Hrp59, an hnRNP M protein in Chironomus and Drosophila, binds to exonic splicing enhancers and is required for expression of a subset of mRNAs.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	TAS Traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in pole cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pole plasm oskar mRNA localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in segmentation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in omega speckle	IDA Inferred from Direct Assay more info	PubMed
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: rumpelstiltskin

Names: CG9373-PA; CG9373-PB; Hrp59; heterogeneous nuclear ribonucleoprotein M; heterogeneous nuclear ribonucleoprotein S5; p75; rump-PA; rump-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9505853..9510324 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260075.2 → NP_001247004.1 rumpelstiltskin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247004.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6Z1

Conserved Domains (2) summary

COG0724
Location:50 → 131

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12385
Location:58 → 133

RRM1_hnRNPM_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
NM_141642.3 → NP_649899.1 rumpelstiltskin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649899.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VHC7

Related

FBpp0081601

Conserved Domains (5) summary

TIGR01628
Location:48 → 435

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

COG0724
Location:543 → 631

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12385
Location:58 → 133

RRM1_hnRNPM_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cd12386
Location:234 → 307

RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cl17169
Location:565 → 630

RRM_SF; RNA recognition motif (RRM) superfamily