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    Ac76E Adenylyl cyclase 76E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ac76Eprovided by FlyBase
    Official Full Name
    Adenylyl cyclase 76Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004852
    Locus tag
    Dmel_CG7978
    See related
    AllianceGenome:FB:FBgn0004852
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC 76E; ac76e; AC76E; CG7978; DAC2; DAC76E; dADCY2; Dmel\CG7978
    Summary
    Enables adenylate cyclase activity. Involved in instar larval or pupal development; regulation of growth; and response to starvation. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; embryonic/larval hindgut; embryonic/larval ureter; gastric caecum; and gland. Orthologous to human ADCY2 (adenylate cyclase 2); ADCY4 (adenylate cyclase 4); and ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ac76E in Genome Data Viewer
    Location:
    76D6-76D7; 3-46 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19939287..19977960)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19932387..19971060)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45678 Neighboring gene RhoGDI Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila FoxO regulates organism size and stress resistance through an adenylate cyclase. Mattila J, et al. Mol Cell Biol, 2009 Oct. PMID 19651894, Free PMC Article
    2. The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase. Levin LR, et al. Cell, 1992 Feb 7. PMID 1739965
    3. A calcium-inhibited Drosophila adenylyl cyclase. Iourgenko V, et al. Biochim Biophys Acta, 2000 Feb 2. PMID 10656970
    4. A quantitative study of the Ca2+/calmodulin sensitivity of adenylyl cyclase in Aplysia, Drosophila, and rat. Yovell Y, et al. J Neurochem, 1992 Nov. PMID 1402918
    5. Discovery of levodopa-induced dyskinesia-associated genes using genomic studies in patients and Drosophila behavioral analyses. Yoon W, et al. Commun Biol, 2022 Aug 25. PMID 36008531, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in instar larval or pupal development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase 76E
    Names
    Ac76E-PA
    Ac76E-PB
    AdenylateCyclase E
    CG7978-PA
    CG7978-PB
    adenylyl cyclase
    NP_001246838.1
    NP_524173.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19939287..19977960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259909.2 → NP_001246838.1  adenylyl cyclase 76E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246838.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDD2
      Conserved Domains (4) summary
      smart00044
      Location:259 → 467
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1101 → 1305
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam05466
      Location:510 → 667
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16214
      Location:67 → 289
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

    2. NM_079449.4 → NP_524173.2  adenylyl cyclase 76E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524173.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77247, Q8MRK9, Q9VW60
      Related
      FBpp0074666
      Conserved Domains (4) summary
      smart00044
      Location:259 → 467
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      pfam00211
      Location:1101 → 1300
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam05466
      Location:510 → 667
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam16214
      Location:67 → 289
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDD2 M9NDD2
    Q9VW60.3 Q9VW60

    Gene LinkOut

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