Lrpprc2 Leucine-rich pentatricopeptide repeat containing 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Lrpprc2provided by FlyBase
Official Full Name: Leucine-rich pentatricopeptide repeat containing 2provided by FlyBase
Primary source: FLYBASE:FBgn0027794
Locus tag: Dmel_CG14786
See related: AllianceGenome:FB:FBgn0027794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14786; Dmel\CG14786; DmLrpprc2; EG:BACN32G11.3; lrpprc2; ppr
Summary: Predicted to enable mRNA 3'-UTR binding activity. Involved in several processes, including regulation of mitochondrial gene expression; regulation of mitochondrial mRNA stability; and regulation of opsin-mediated signaling pathway. Located in mitochondrion. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; gastric caecum; and gut section. Used to study French Canadian Leigh disease and Leigh disease. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (1457175..1460617, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1351208..1354650, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of mitochondrial mRNA stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IC Inferred by Curator more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain