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    Cdk2 Cyclin-dependent kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42453, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Cdk2provided by FlyBase
    Official Full Name
    Cyclin-dependent kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0004107
    Locus tag
    Dmel_CG10498
    See related
    AllianceGenome:FB:FBgn0004107
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc2c; Cdc2c; CDC2c; CDC2C; cdk2; CDK2; CDK2/CDC2c; CG10498; Dcdc2c; dCdk2; Dmcdc2c; DmCdc2c; DmCdk2; Dmel\CG10498; S(Sev-CycE)3A
    Summary
    Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including Malpighian tubule primordium; antennal primordium; ganglia; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2) and CDK3 (cyclin dependent kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdk2 in Genome Data Viewer
    Location:
    92F10-92F10; 3-69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20735623..20738414)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16561345..16564136)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-995 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin-dependent kinases: a new cell cycle motif? Pines J, et al. Trends Cell Biol, 1991 Nov. PMID 14731542
    2. Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant. Lehner CF, et al. EMBO J, 1990 Nov. PMID 2120045, Free PMC Article
    3. Divide and differentiate: CDK/Cyclins and the art of development. Ishidate T, et al. Cell Cycle, 2014. PMID 24675894, Free PMC Article
    4. Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation. Faradji F, et al. Cell Cycle, 2011 Mar 1. PMID 21311225
    5. MAPK3 at the Autism-Linked Human 16p11.2 Locus Influences Precise Synaptic Target Selection at Drosophila Larval Neuromuscular Junctions. Park SM, et al. Mol Cells, 2017 Feb. PMID 28196412, Free PMC Article

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CycE and Cdk2 are required for germline stem cell proliferation.
      Title: Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals.
    2. follicular stem cell function was substantially restored by expressing either excess DE-cadherin or excess E2F1/DP, the transcription factor normally activated by CycE-Cdk2 phosphorylation of retinoblastoma proteins
      Title: Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells.
    3. APC/C-Fzr activity is periodically inhibited by CycE-Cdk2, to prevent relicensing in S-phase cells.
      Title: The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.
    4. phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2
      Title: Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of receptor signaling pathway via JAK-STAT IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclin-dependent kinase 2
    Names
    CG10498-PA
    CG10498-PB
    CG10498-PC
    Cdk2-PA
    Cdk2-PB
    Cdk2-PC
    cdc2c
    cyclin E
    cyclin-dependent kinase 2
    NP_001163666.1
    NP_524420.1
    NP_732544.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20735623..20738414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170195.3 → NP_001163666.1  Cyclin-dependent kinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23573, Q0KI40, Q9TXB2, Q9VDJ4
      UniProtKB/TrEMBL
      E1JIR3
      Conserved Domains (2) summary
      PLN00009
      Location:5 → 293
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07835
      Location:8 → 287
      STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase

    2. NM_079696.6 → NP_524420.1  Cyclin-dependent kinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23573, Q0KI40, Q9TXB2, Q9VDJ4
      UniProtKB/TrEMBL
      E1JIR3
      Related
      FBpp0083330
      Conserved Domains (2) summary
      PLN00009
      Location:5 → 293
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07835
      Location:8 → 287
      STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase

    3. NM_169916.3 → NP_732544.1  Cyclin-dependent kinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23573, Q0KI40, Q9TXB2, Q9VDJ4
      UniProtKB/TrEMBL
      E1JIR3
      Related
      FBpp0083329
      Conserved Domains (2) summary
      PLN00009
      Location:5 → 293
      PLN00009; cyclin-dependent kinase A; Provisional
      cd07835
      Location:8 → 287
      STKc_CDK1_CdkB_like; Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JIR3 E1JIR3
    P23573.1 P23573

    Gene LinkOut

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