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    blot bloated tubules [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39939, updated on 27-Dec-2024

    Summary

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    Official Symbol
    blotprovided by FlyBase
    Official Full Name
    bloated tubulesprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027660
    Locus tag
    Dmel_CG3897
    See related
    AllianceGenome:FB:FBgn0027660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3897; DmBLOT; Dmel\CG3897; l(3)1658
    Summary
    Predicted to enable glycine:sodium symporter activity and neurotransmitter:sodium symporter activity. Predicted to be involved in amino acid transport; neurotransmitter transport; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule; Malpighian tubule primordium; Malpighian tubule tip cell primordium; anterior-posterior subdivision of organism; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See blot in Genome Data Viewer
    Location:
    74B1-74B2; 3-45 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17396031..17421514, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17389131..17414614, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:noe Neighboring gene Secretory 3 Neighboring gene Cytochrome c oxidase subunit 7B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. bloated tubules (blot) encodes a Drosophila member of the neurotransmitter transporter family required for organisation of the apical cytocortex. Johnson K, et al. Dev Biol, 1999 Aug 15. PMID 10433833
    2. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
    3. Activation of Ftz-F1-Responsive Genes through Ftz/Ftz-F1 Dependent Enhancers. Field A, et al. PLoS One, 2016. PMID 27723822, Free PMC Article
    4. Novel synthetic Medea selfish genetic elements drive population replacement in Drosophila; a theoretical exploration of Medea-dependent population suppression. Akbari OS, et al. ACS Synth Biol, 2014 Dec 19. PMID 23654248, Free PMC Article
    5. Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster. Thimgan MS, et al. J Exp Biol, 2006 Sep. PMID 16916974

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycine:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter:sodium symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bloated tubules
    Names
    CG3897-PA
    CG3897-PB
    CG3897-PC
    CG3897-PD
    CG3897-PE
    blated tubules
    blot-PA
    blot-PB
    blot-PC
    blot-PD
    blot-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17396031..17421514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170636.2 → NP_730263.1  bloated tubules, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730263.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA83, Q8IQQ7
      Related
      FBpp0074994
      Conserved Domains (1) summary
      cd06857
      Location:219 → 659
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_079401.3 → NP_524125.2  bloated tubules, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524125.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA83, Q8IQQ7
      Related
      FBpp0074995
      Conserved Domains (1) summary
      cd06857
      Location:219 → 659
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_170637.2 → NP_730264.1  bloated tubules, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC7, Q9VVG3
      Related
      FBpp0074996
      Conserved Domains (1) summary
      cd06857
      Location:12 → 452
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001300164.1 → NP_001287093.1  bloated tubules, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC7, Q8IQQ6
      Conserved Domains (1) summary
      cd06857
      Location:52 → 492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_170638.2 → NP_730265.1  bloated tubules, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAC7, Q8IQQ6
      Related
      FBpp0074997
      Conserved Domains (1) summary
      cd06857
      Location:52 → 492
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQQ6 Q8IQQ6
    Q8IQQ7 Q8IQQ7
    Q95T09 Q95T09
    Q9U975 Q9U975
    Q9VVG3 Q9VVG3

    Gene LinkOut

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