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    frac faulty attraction [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38850, updated on 17-Dec-2024

    Summary

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    Official Symbol
    fracprovided by FlyBase
    Official Full Name
    faulty attractionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035798
    Locus tag
    Dmel_CG7526
    See related
    AllianceGenome:FB:FBgn0035798
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7526; CT16044; Dmel\CG7526; Frac
    Summary
    Predicted to enable calcium ion binding activity. Involved in axon target recognition. Predicted to be located in extracellular matrix. Is expressed in several structures, including dorsal head epidermis; embryonic hindgut; larval muscle cell; larval muscle system; and muscle attachment site. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See frac in Genome Data Viewer
    Location:
    66A5-66A5; 3-21 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7562610..7569499)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7555710..7562599)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene missing minor mitochondria Neighboring gene testis-specific gamma-tubulin ring protein 84

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Zhang X, et al. Sci Total Environ, 2023 Aug 25. PMID 37196938
    2. Drosophila MMP2 regulates the matrix molecule faulty attraction (Frac) to promote motor axon targeting in Drosophila. Miller CM, et al. J Neurosci, 2011 Apr 6. PMID 21471368, Free PMC Article
    3. The genetic basis of incipient sexual isolation in Drosophila melanogaster. Yamamoto A, et al. Proc Biol Sci, 2024 Aug. PMID 39045689, Free PMC Article
    4. High throughput in vivo functional validation of candidate congenital heart disease genes in Drosophila. Zhu JY, et al. Elife, 2017 Jan 20. PMID 28084990, Free PMC Article
    5. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Upadhyay A, et al. Mol Neurodegener, 2023 Sep 14. PMID 37710351, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon target recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    faulty attraction
    Names
    CG7526-PC
    CG7526-PD
    CG7526-PE
    CG7526-PF
    CG7526-PG
    frac-PC
    frac-PD
    frac-PE
    frac-PF
    frac-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7562610..7569499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139880.4 → NP_648137.3  faulty attraction, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648137.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN72, B7Z0D5, Q9VS89
      Conserved Domains (6) summary
      cd00033
      Location:1110 → 1170
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07645
      Location:676 → 715
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:396 → 415
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:945 → 980
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:550 → 586
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl03620
      Location:1468 → 1536
      DUF5011; Domain of unknown function (DUF5011)

    2. NM_206292.3 → NP_996014.2  faulty attraction, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996014.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN72, B7Z0D5, Q9VS89
      Conserved Domains (6) summary
      cd00033
      Location:1110 → 1170
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07645
      Location:676 → 715
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:396 → 415
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:945 → 980
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:550 → 586
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl03620
      Location:1468 → 1536
      DUF5011; Domain of unknown function (DUF5011)

    3. NM_001274602.1 → NP_001261531.1  faulty attraction, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261531.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN72, M9PHP7
      Conserved Domains (5) summary
      cd00033
      Location:919 → 979
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:552 → 581
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:396 → 415
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:754 → 789
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl03620
      Location:1277 → 1345
      DUF5011; Domain of unknown function (DUF5011)

    4. NM_001144433.3 → NP_001137905.1  faulty attraction, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN72, B7Z0D5, Q9VS89
      Conserved Domains (6) summary
      cd00033
      Location:1110 → 1170
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07645
      Location:676 → 715
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:396 → 415
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:945 → 980
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:550 → 586
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl03620
      Location:1468 → 1536
      DUF5011; Domain of unknown function (DUF5011)

    5. NM_001274603.1 → NP_001261532.1  faulty attraction, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN72, M9PHP7
      Conserved Domains (5) summary
      cd00033
      Location:919 → 979
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00179
      Location:552 → 581
      EGF_CA; Calcium-binding EGF-like domain
      pfam12662
      Location:396 → 415
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:754 → 789
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl03620
      Location:1277 → 1345
      DUF5011; Domain of unknown function (DUF5011)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHP7 M9PHP7
    Q8MQJ4 Q8MQJ4
    Q9VS89 Q9VS89

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