Abi Abelson interacting protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Abiprovided by FlyBase
Official Full Name: Abelson interacting proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0020510
Locus tag: Dmel_CG9749
See related: AllianceGenome:FB:FBgn0020510
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: abi; Abi-1; Ablphilin; CG9749; dAbi; Dmel\CG9749
Summary: Enables cadherin binding activity. Involved in several processes, including centripetally migrating follicle cell migration; plasma membrane bounded cell projection organization; and positive regulation of cellular component biogenesis. Located in several cellular components, including basal cortex; lamellipodium membrane; and perinuclear region of cytoplasm. Part of SCAR complex. Is expressed in several structures, including adult head; ganglia; neuron projection bundle; photoreceptor neurons; and synaptic neuropil. Orthologous to several human genes including ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88A9-88A9; 3-54 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14119262..14122420, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9944984..9948142, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
Title: The Abl-interactor Abi suppresses the function of the BRAG2 GEF family member Schizo.
The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance.
Title: The first quarter of the C-terminal domain of Abelson regulates the WAVE regulatory complex and Enabled in axon guidance.
BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis
Title: BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis.
Data suggest that abi and Abl have an antagonistic interaction in Drosophila axonogenesis and synaptogenesis, which possibly occurs through the modulation of F-actin reorganization.
Title: Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis.
These findings suggest that the reciprocal regulation of Abi phosphorylation by Abl and PTP61F may regulate the localization and stability of Abi and may regulate the formation of lamella.
Title: The involvement of Abl and PTP61F in the regulation of Abi protein localization and stability and lamella formation in Drosophila S2 cells.
SCAR is regulated by Abi, Kette, and Sra1, which may help to ensure that Arp2/3 activation and the generation of actin-based protrusions remain strictly dependant on local GTPase signaling
Title: Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions.
The Activation of Abi results in the formation of ectopic bristles, a phenotype that is suppressed by a reduction of wasp activity but is not affected by the reduction of wave function.
Title: Abi activates WASP to promote sensory organ development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system neuron axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centripetally migrating follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of planar polarity of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCAR complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCAR complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in actin-based cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in basal cortex	IDA Inferred from Direct Assay more info	PubMed
located_in basal part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: abelson interacting protein

Names: Abi-PA; Abi-PB; Abi-PC; Abi-PD; Abi-PE; Abi-PF; CG9749-PA; CG9749-PB; CG9749-PC; CG9749-PD; CG9749-PE; CG9749-PF; abelson interactor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14119262..14122420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260161.1 → NP_001247090.1 abelson interacting protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247090.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH51

Conserved Domains (2) summary

cd11826
Location:418 → 469

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR
NM_001275631.1 → NP_001262560.1 abelson interacting protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262560.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y0S9

Conserved Domains (2) summary

cd11826
Location:419 → 470

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR
NM_001275630.1 → NP_001262559.1 abelson interacting protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262559.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KH51

Conserved Domains (2) summary

cd11826
Location:418 → 469

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR
NM_057915.5 → NP_477263.1 abelson interacting protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477263.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y0S9

Related

FBpp0082371

Conserved Domains (2) summary

cd11826
Location:419 → 470

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR
NM_001260162.1 → NP_001247091.1 abelson interacting protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247091.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K774

Conserved Domains (2) summary

cd11826
Location:423 → 474

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR
NM_001104315.2 → NP_001097785.1 abelson interacting protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097785.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9Y0S9

Conserved Domains (2) summary

cd11826
Location:419 → 470

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:105 → 168

Abi_HHR; Abl-interactor HHR